ETV4 explained

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.^{[1] [2] [3]}

Disease marker

Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous tumors, the former grows in the bones most commonly affecting the arms, legs, hips, and spine, while the later affects the soft tissue in the chest, foot, pelvis and spine.

Further reading

• Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE . 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors . Genomics . 25 . 1 . 256–63 . Jan 1995 . 7774926 . 10.1016/0888-7543(95)80133-7 . free .
• Liu SH, Peng BH, Ma JT, Liu YC, Ng SY . Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor . Developmental Genetics . 16 . 3 . 229–40 . 1995 . 7796532 . 10.1002/dvg.1020160303 .
• Friedman LS, Ostermeyer EA, Lynch ED, Szabo CI, Anderson LA, Dowd P, Lee MK, Rowell SE, Boyd J, King MC . The search for BRCA1 . Cancer Research . 54 . 24 . 6374–82 . Dec 1994 . 7987831 .
• Higashino F, Yoshida K, Fujinaga Y, Kamio K, Fujinaga K . Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family . Nucleic Acids Research . 21 . 3 . 547–53 . Feb 1993 . 8441666 . 309151 . 10.1093/nar/21.3.547 .
• Urano F, Umezawa A, Hong W, Kikuchi H, Hata J . A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma . Biochemical and Biophysical Research Communications . 219 . 2 . 608–12 . Feb 1996 . 8605035 . 10.1006/bbrc.1996.0281 .
• Coutte L, Monté D, Baert J, de Launoit Y . Genomic organization of the human e1af gene,a member of Ets transcription factors . Gene . 240 . 1 . 201–7 . Nov 1999 . 10564827 . 10.1016/S0378-1119(99)00400-X .
• Mastrangelo T, Modena P, Tornielli S, Bullrich F, Testi MA, Mezzelani A, Radice P, Azzarelli A, Pilotti S, Croce CM, Pierotti MA, Sozzi G . A novel zinc finger gene is fused to EWS in small round cell tumor . Oncogene . 19 . 33 . 3799–804 . Aug 2000 . 10949935 . 10.1038/sj.onc.1203762 . free .
• Davidson B, Goldberg I, Gotlieb WH, Kopolovic J, Ben-Baruch G, Reich R . PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma . Clinical Cancer Research . 9 . 4 . 1412–9 . Apr 2003 . 12684413 .
• Span PN, Manders P, Heuvel JJ, Beex LV, Sweep CG . E1AF expression levels are not associated with prognosis in human breast cancer . Breast Cancer Research and Treatment . 79 . 1 . 129–31 . May 2003 . 12779089 . 10.1023/A:1023338424677 . 6629346 .
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A . The human plasma proteome: a nonredundant list developed by combination of four separate sources . Molecular & Cellular Proteomics . 3 . 4 . 311–26 . Apr 2004 . 14718574 . 10.1074/mcp.M300127-MCP200 . free .
• Liu Y, Borchert GL, Phang JM . Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells . The Journal of Biological Chemistry . 279 . 18 . 18694–700 . Apr 2004 . 14976201 . 10.1074/jbc.M308136200 . free .
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions . Genome Research . 14 . 9 . 1711–8 . Sep 2004 . 15342556 . 515316 . 10.1101/gr.2435604 .
• Davidson B, Goldberg I, Tell L, Vigdorchik S, Baekelandt M, Berner A, Kristensen GB, Reich R, Kopolovic J . The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions . Clinical & Experimental Metastasis . 21 . 3 . 191–9 . 2004 . 15387369 . 10.1023/B:CLIN.0000037703.37275.35 . 22579184 .
• Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P, Van Seuningen I . The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells . The Biochemical Journal . 386 . Pt 1 . 35–45 . Feb 2005 . 15461591 . 1134764 . 10.1042/BJ20040706 .
• Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z, Yang Y, Niu Z, Liu W, Chen X, Hu Y, Gu J . Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator . The Journal of Biological Chemistry . 280 . 13 . 12503–16 . Apr 2005 . 15611127 . 10.1074/jbc.M413631200 . free .
• Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M . E1AF degradation by a ubiquitin-proteasome pathway . Biochemical and Biophysical Research Communications . 327 . 2 . 575–80 . Feb 2005 . 15629152 . 10.1016/j.bbrc.2004.12.045 .
• Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K . Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis . Carcinogenesis . 26 . 5 . 892–9 . May 2005 . 15695237 . 10.1093/carcin/bgi029 . 10.1.1.567.1603 .

Notes and References

1. Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K . Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21 . Genomics . 28 . 2 . 357–9 . Jul 1995 . 8530053 . 10.1006/geno.1995.1158 .
2. Web site: Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF).
3. Web site: ETV4 Gene - GeneCards ETV4 Protein ETV4 Antibody. www.genecards.org. 2019-10-20.