ETH-LAD explained
| Verifiedfields: | changed |
| Watchedfields: | changed |
| Verifiedrevid: | 414446334 |
| Iupac Name: | (6aR,9R)-N,N-diethyl-7-ethyl-4,6,6a,7,8,9-
hexahydroindolo-[4,3-''fg'']quinoline-9-carboxamide |
| Width: | 200 |
| Legal De: | NpSG |
| Legal Uk: | Class A |
| Legal Status: | Illegal in France[1] |
| Routes Of Administration: | Oral |
| Metabolism: | Hepatic |
| Excretion: | Renal |
| Cas Number: | 65527-62-0 |
| Pubchem: | 44457783 |
| Chemspiderid: | 21106300 |
| Chembl: | 22694 |
| Unii: | 21Z2736X9Q |
| C: | 21 |
| H: | 27 |
| N: | 3 |
| O: | 1 |
| Smiles: | CCN(C([C@@H]1C=C2C3=CC=CC4=C3C(C[C@H]2N(CC)C1)=CN4)=O)CC |
| Stdinchi: | 1S/C21H27N3O/c1-4-23(5-2)21(25)15-10-17-16-8-7-9-18-20(16)14(12-22-18)11-19(17)24(6-3)13-15/h7-10,12,15,19,22H,4-6,11,13H2,1-3H3/t15-,19-/m1/s1 |
| Stdinchikey: | MYNOUXJLOHVSMQ-DNVCBOLYSA-N |
| Synonyms: | ETH-LAD, 6-ethyl-6-nor-Lysergic acid diethylamide |
ETH-LAD, 6-ethyl-6-nor-lysergic acid diethylamide is an analogue of LSD. Its human psychopharmacology was first described by Alexander Shulgin in the book TiHKAL. ETH-LAD is a psychedelic drug similar to LSD, and is slightly more potent than LSD itself,[2] with an active dose reported at between 20 and 150 micrograms. ETH-LAD has subtly different effects to LSD, described as less demanding. The true tryptamine counterpart of ETH-LAD is MET, a simplified version of this structure.
Legality
On June 10, 2014, the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that ETH-LAD be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use.[3] The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015.[4]
ETH-LAD is illegal in Switzerland as of December 2015.[5]
See also
Further reading
- Hoffman AJ, Nichols DE . Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives . Journal of Medicinal Chemistry . 28 . 9 . 1252–5 . September 1985 . 4032428. 10.1021/jm00147a022 .
- Watts VJ, Lawler CP, Fox DR, Neve KA, Nichols DE, Mailman RB . LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors . Psychopharmacology . 118 . 4 . 401–9 . April 1995 . 7568626. 10.1007/BF02245940 . 21484356 .
- Niwaguchi T, Nakahara Y, Ishii H . [Studies on lysergic acid diethylamide and related compounds. IV. Syntheses of various amide derivatives of norlysergic acid and related compounds] . Yakugaku Zasshi . 96 . 5 . 673–8 . May 1976 . 987200 . 10.1248/yakushi1947.96.5_673. free .
- Book: Pfaff RC, Huang X, Marona-Lewicka D, Oberlender R, Nichols DE . http://archives.drugabuse.gov/pdf/monographs/146.pdf . Lysergamides Revisited . NIDA Research Monograph 146: Hallucinogens: An Update . 52 . 1994 . United States Department of Health and Human Services . https://web.archive.org/web/20150723031539/http://archives.drugabuse.gov/pdf/monographs/146.pdf . 2015-07-23 .
- Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Stratford A, Nichols DE, Halberstadt AL . 6 . 6 -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD) . Drug Testing and Analysis . 9 . 10 . 1641–1649 . October 2017 . 28342178. 6230477 . 10.1002/dta.2196 .
External links
Notes and References
- Web site: 20 May 2021. Arrêté du 20 mai 2021 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants. www.legifrance.gouv.fr. fr.
- Hoffman AJ, Nichols DE . Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives . Journal of Medicinal Chemistry . 28 . 9 . 1252–5 . September 1985 . 4032428 . 10.1021/jm00147a022 .
- Web site: Update of the Generic Definition for Tryptamines . UK Home Office . 10 June 2014 . 10 June 2014 . Advisory Council on the Misuse of Drugs (ACMD) . 12.
- Web site: The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014 .
- Web site: Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien . Der Bundesrat.
