| Developer: | Blue Shift |
| Publisher: | Sega |
| Platforms: | Xbox, PS2 |
| Released: | Xbox April 6, 2004 PS2 May 4, 2004 |
| Genre: | Sports |
| Modes: | Single player Multiplayer |
ESPN Major League Baseball (ESPN MLB) is a baseball game published by Sega and released in 2004 for the Xbox and PlayStation 2. It is the successor to World Series Baseball 2K3, and the only MLB-licensed Sega game to be released under the ESPN branding.
The game was given generally positive reviews.