ERP29 explained

Endoplasmic reticulum protein 29 (ERp29) is a chaperone protein that in humans is encoded by the ERP29 gene.

Function

ERp29 is a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide-isomerase family.^[1] However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase.^[1] The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.^[2]

Further reading

• Hubbard MJ . Functional proteomics: The goalposts are moving . Proteomics . 2 . 9 . 1069–78 . Sep 2002 . 12362325 . 10.1002/1615-9861(200209)2:9<1069::AID-PROT1069>3.0.CO;2-R . 46402626 .
• Mkrtchian S, Sandalova T . ERp29, an unusual redox-inactive member of the thioredoxin family . Antioxidants & Redox Signaling . 8 . 3–4 . 325–37 . 2006 . 16677078 . 10.1089/ars.2006.8.325 .
• Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R . Human liver protein map: a reference database established by microsequencing and gel comparison . Electrophoresis . 13 . 12 . 992–1001 . Dec 1992 . 1286669 . 10.1002/elps.11501301201 . 23518983 .
• Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF . Human liver protein map: update 1993 . Electrophoresis . 14 . 11 . 1216–22 . Nov 1993 . 8313870 . 10.1002/elps.11501401181 . 33424554 .
• Mkrtchian S, Fang C, Hellman U, Ingelman-Sundberg M . A stress-inducible rat liver endoplasmic reticulum protein, ERp29 . European Journal of Biochemistry . 251 . 1–2 . 304–13 . Jan 1998 . 9492298 . 10.1046/j.1432-1327.1998.2510304.x . free .
• Ferrari DM, Nguyen Van P, Kratzin HD, Söling HD . ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif . European Journal of Biochemistry . 255 . 3 . 570–9 . Aug 1998 . 9738895 . 10.1046/j.1432-1327.1998.2550570.x . free .
• Hubbard MJ, McHugh NJ . Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping . Electrophoresis . 21 . 17 . 3785–96 . Nov 2000 . 11271497 . 10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2 . 42538820 .
• Shnyder SD, Hubbard MJ . ERp29 is a ubiquitous resident of the endoplasmic reticulum with a distinct role in secretory protein production . The Journal of Histochemistry and Cytochemistry . 50 . 4 . 557–66 . Apr 2002 . 11897809 . 10.1177/002215540205000413 . free .
• Sargsyan E, Baryshev M, Backlund M, Sharipo A, Mkrtchian S . Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29 . Gene . 285 . 1–2 . 127–39 . Feb 2002 . 12039039 . 10.1016/S0378-1119(02)00417-1 . 10.1.1.593.9369 .
• Basrur V, Yang F, Kushimoto T, Higashimoto Y, Yasumoto K, Valencia J, Muller J, Vieira WD, Watabe H, Shabanowitz J, Hearing VJ, Hunt DF, Appella E . Proteomic analysis of early melanosomes: identification of novel melanosomal proteins . Journal of Proteome Research . 2 . 1 . 69–79 . 2003 . 12643545 . 10.1021/pr025562r .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Cheretis C, Dietrich F, Chatzistamou I, Politi K, Angelidou E, Kiaris H, Mkrtchian S, Koutselini H . Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma . The American Journal of Dermatopathology . 28 . 5 . 410–2 . Oct 2006 . 17012915 . 10.1097/01.dad.0000211521.49810.ac . 1661765 .
• Zheng J, Liu X, Yan X, Dai L, Ji C . Purification and structural characterization of human ERp29 . Protein and Peptide Letters . 13 . 8 . 753–9 . 2006 . 17073718 . 10.2174/092986606777841190 .
• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF . Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes . Journal of Proteome Research . 5 . 11 . 3135–44 . Nov 2006 . 17081065 . 10.1021/pr060363j .
• Lippert U, Diao D, Barak NN, Ferrari DM . Conserved structural and functional properties of D-domain containing redox-active and -inactive protein disulfide isomerase-related protein chaperones . The Journal of Biological Chemistry . 282 . 15 . 11213–20 . Apr 2007 . 17296603 . 10.1074/jbc.M604440200 . 25822309 . free .

Notes and References

1. Galligan JJ, Petersen DR . The human protein disulfide isomerase gene family . Human Genomics . 6 . 6. July 2012 . 23245351 . 3500226 . 10.1186/1479-7364-6-6 . 1 . free .
2. Web site: Entrez Gene: ERP29 endoplasmic reticulum protein 29.