ERRFI1 explained

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.^{[1] [2] [3] [4] [5]}

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).

Interactions

ERRFI1 has been shown to interact with Stratifin^[6] and CDC42.

Further reading

• Zhang YW, Vande Woude GF . Mig-6, signal transduction, stress response and cancer . Cell Cycle . 6 . 5 . 507–13 . March 2007 . 17351343 . 10.4161/cc.6.5.3928 . free .
• Wick M, Bürger C, Funk M, Müller R . Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation . Experimental Cell Research . 219 . 2 . 527–35 . August 1995 . 7641805 . 10.1006/excr.1995.1261 .
• Hackel PO, Gishizky M, Ullrich A . Mig-6 is a negative regulator of the epidermal growth factor receptor signal . Biological Chemistry . 382 . 12 . 1649–62 . December 2001 . 11843178 . 10.1515/BC.2001.200 . 23424592 .
• Tsunoda T, Inokuchi J, Baba I, Okumura K, Naito S, Sasazuki T, Shirasawa S . A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6 . Cancer Research . 62 . 20 . 5668–71 . October 2002 . 12384522 .
• Saarikoski ST, Rivera SP, Hankinson O . Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia . FEBS Letters . 530 . 1–3 . 186–90 . October 2002 . 12387890 . 10.1016/S0014-5793(02)03475-0 . 37181106 .
• Anastasi S, Fiorentino L, Fiorini M, Fraioli R, Sala G, Castellani L, Alemà S, Alimandi M, Segatto O . Feedback inhibition by RALT controls signal output by the ErbB network . Oncogene . 22 . 27 . 4221–34 . July 2003 . 12833145 . 10.1038/sj.onc.1206516 . 26020025 .
• Xu D, Makkinje A, Kyriakis JM . Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function . The Journal of Biological Chemistry . 280 . 4 . 2924–33 . January 2005 . 15556944 . 10.1074/jbc.M408907200 . free .
• Keeton AB, Messina JL . Modulation of Elk-dependent-transcription by Gene33 . Journal of Cellular Biochemistry . 94 . 6 . 1190–8 . April 2005 . 15696545 . 10.1002/jcb.20370 . 3023317 .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Molecular & Cellular Proteomics . 4 . 6 . 785–95 . June 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Anastasi S, Sala G, Huiping C, Caprini E, Russo G, Iacovelli S, Lucini F, Ingvarsson S, Segatto O . Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin . Oncogene . 24 . 28 . 4540–8 . June 2005 . 15856022 . 10.1038/sj.onc.1208658 . free . 1946/21931 . free .
• Ballarò C, Ceccarelli S, Tiveron C, Tatangelo L, Salvatore AM, Segatto O, Alemà S . Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype . EMBO Reports . 6 . 8 . 755–61 . August 2005 . 16007071 . 1369136 . 10.1038/sj.embor.7400458 .
• Zhang YW, Staal B, Su Y, Swiatek P, Zhao P, Cao B, Resau J, Sigler R, Bronson R, Vande Woude GF . Evidence that MIG-6 is a tumor-suppressor gene . Oncogene . 26 . 2 . 269–76 . January 2007 . 16819504 . 10.1038/sj.onc.1209790 . free .

Notes and References

1. Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM . Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress . The Journal of Biological Chemistry . 275 . 23 . 17838–47 . June 2000 . 10749885 . 3668664 . 10.1074/jbc.M909735199 . free .
2. Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK . Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity . Nucleic Acids Research . 17 . 16 . 6651–67 . August 1989 . 2780291 . 318357 . 10.1093/nar/17.16.6651 .
3. Fiorini M, Ballarò C, Sala G, Falcone G, Alemà S, Segatto O . Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control . Oncogene . 21 . 42 . 6530–9 . September 2002 . 12226756 . 10.1038/sj.onc.1205823 . 23762528 .
4. Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alemà S, Benedetti P, Segatto O . Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain . Molecular and Cellular Biology . 20 . 20 . 7735–50 . October 2000 . 11003669 . 86354 . 10.1128/MCB.20.20.7735-7750.2000 .
5. Web site: Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1.
6. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Molecular & Cellular Proteomics . 4 . 6 . 785–95 . June 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .