ERO1L explained

ERO1-like protein alpha is a protein that in humans is encoded by the ERO1L gene.^{[1] [2]}

Interactions

ERO1L has been shown to interact with TXNDC4^[3] and P4HB.^{[3] [4]}

Further reading

• Pagani M, Fabbri M, Benedetti C, Fassio A, Pilati S, Bulleid NJ, Cabibbo A, Sitia R . Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response . The Journal of Biological Chemistry . 275 . 31 . 23685–92 . August 2000 . 10818100 . 10.1074/jbc.M003061200 . free .
• Benham AM, Cabibbo A, Fassio A, Bulleid N, Sitia R, Braakman I . The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha . The EMBO Journal . 19 . 17 . 4493–502 . September 2000 . 10970843 . 302061 . 10.1093/emboj/19.17.4493 .
• Pagani M, Pilati S, Bertoli G, Valsasina B, Sitia R . The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function . FEBS Letters . 508 . 1 . 117–20 . November 2001 . 11707280 . 10.1016/S0014-5793(01)03034-4 . 34968489 .
• Mezghrani A, Fassio A, Benham A, Simmen T, Braakman I, Sitia R . Manipulation of oxidative protein folding and PDI redox state in mammalian cells . The EMBO Journal . 20 . 22 . 6288–96 . November 2001 . 11707400 . 125306 . 10.1093/emboj/20.22.6288 .
• Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R . ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family . The EMBO Journal . 21 . 4 . 835–44 . February 2002 . 11847130 . 125352 . 10.1093/emboj/21.4.835 .
• Tsai B, Rapoport TA . Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1 . The Journal of Cell Biology . 159 . 2 . 207–16 . October 2002 . 12403808 . 2173060 . 10.1083/jcb.200207120 .
• Gess B, Hofbauer KH, Wenger RH, Lohaus C, Meyer HE, Kurtz A . The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha . European Journal of Biochemistry . 270 . 10 . 2228–35 . May 2003 . 12752442 . 10.1046/j.1432-1033.2003.03590.x . 2020-09-09 . 2021-10-16 . https://web.archive.org/web/20211016203800/https://www.zora.uzh.ch/id/eprint/1290/1/Gess2003MaV.pdf . dead .
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Research . 13 . 10 . 2265–70 . October 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
• Anelli T, Alessio M, Bachi A, Bergamelli L, Bertoli G, Camerini S, Mezghrani A, Ruffato E, Simmen T, Sitia R . Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44 . The EMBO Journal . 22 . 19 . 5015–22 . October 2003 . 14517240 . 204474 . 10.1093/emboj/cdg491 .
• Bertoli G, Simmen T, Anelli T, Molteni SN, Fesce R, Sitia R . Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum . The Journal of Biological Chemistry . 279 . 29 . 30047–52 . July 2004 . 15136577 . 10.1074/jbc.M403192200 . free .
• Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R . Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum . The Journal of Biological Chemistry . 279 . 31 . 32667–73 . July 2004 . 15161913 . 10.1074/jbc.M404992200 . 3919247 . free .
• van Lith M, Hartigan N, Hatch J, Benham AM . PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum . The Journal of Biological Chemistry . 280 . 2 . 1376–83 . January 2005 . 15475357 . 10.1074/jbc.M408651200 . free .
• May D, Itin A, Gal O, Kalinski H, Feinstein E, Keshet E. Eli Keshet . Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer . Oncogene . 24 . 6 . 1011–20 . February 2005 . 15592500 . 10.1038/sj.onc.1208325 . free .
• Otsu M, Bertoli G, Fagioli C, Guerini-Rocco E, Nerini-Molteni S, Ruffato E, Sitia R . Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44 . Antioxidants & Redox Signaling . 8 . 3–4 . 274–82 . 2006 . 16677073 . 10.1089/ars.2006.8.274 .

Notes and References

1. Cabibbo A, Pagani M, Fabbri M, Rocchi M, Farmery MR, Bulleid NJ, Sitia R . ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum . The Journal of Biological Chemistry . 275 . 7 . 4827–33 . February 2000 . 10671517 . 10.1074/jbc.275.7.4827 . free .
2. Web site: Entrez Gene: ERO1L ERO1-like (S. cerevisiae).
3. Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R . ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family . The EMBO Journal . 21 . 4 . 835–44 . February 2002 . 11847130 . 125352 . 10.1093/emboj/21.4.835 .
4. Mezghrani A, Fassio A, Benham A, Simmen T, Braakman I, Sitia R . Manipulation of oxidative protein folding and PDI redox state in mammalian cells . The EMBO Journal . 20 . 22 . 6288–96 . November 2001 . 11707400 . 125306 . 10.1093/emboj/20.22.6288 .