ERH (gene) explained

Symbol:	ER
Enhancer of rudimentary
Pfam:	PF01133
Interpro:	IPR000781
Prosite:	PDOC00732
Scop:	1j24
Tcdb:	3.A.16

In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.^{[1] [2] [3]}

The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.^[4]

From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms. It has been proposed that this protein plays a role in the cell cycle.

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Andersen JS, Lam YW, Leung AK . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 . etal.
• Amente S, Napolitano G, Licciardo P . Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation . FEBS Lett. . 579 . 3 . 683–9 . 2005 . 15670829 . 10.1016/j.febslet.2004.12.045 . 33475235 . etal. free .
• Wan C, Tempel W, Liu ZJ . Structure of the conserved transcriptional repressor enhancer of rudimentary homolog . Biochemistry . 44 . 13 . 5017–23 . 2005 . 15794639 . 10.1021/bi047785w . etal.
• Stelzl U, Worm U, Lalowski M . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . etal. 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.
• Jin T, Guo F, Serebriiskii IG . A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks . Proteins . 68 . 2 . 427–37 . 2007 . 17444515 . 10.1002/prot.21343 . 2003248 . etal. free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Enhancer of rudimentary homolog (ERH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Enhancer of rudimentary homolog (ERH)

Notes and References

1. Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y . Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene . Genomics . 32 . 1 . 125–7 . Sep 1996 . 8786099 . 10.1006/geno.1996.0086 .
2. Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI . The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals . Gene . 186 . 2 . 189–95 . Apr 1997 . 9074495 . 10.1016/S0378-1119(96)00701-9 .
3. Web site: Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila).
4. Wojcik . E. . Murphy . A. M. . Fares . H. . Dang-Vu . K. . Tsubota . S. I. . Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene . Genetics . 138 . 4 . 1163–1170 . 1994 . 10.1093/genetics/138.4.1163 . 7896098 . 1206255.