ERGIC3 explained

Endoplasmic reticulum-Golgi intermediate compartment protein 3 is a protein that in humans is encoded by the ERGIC3 gene.^{[1] [2]} It has been reported to be regulated by micro RNAs and may be important in a cancer.^{[3] [4]}

Further reading

• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Scanlan MJ, Gout I, Gordon CM . Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. . Cancer Immun. . 1 . 4 . 2003 . 12747765 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Breuza L, Halbeisen R, Jenö P . Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. . J. Biol. Chem. . 279 . 45 . 47242–53 . 2004 . 15308636 . 10.1074/jbc.M406644200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . etal. free .
• Nishikawa M, Kira Y, Yabunaka Y, Inoue M . Identification and characterization of endoplasmic reticulum-associated protein, ERp43. . Gene . 386 . 1–2 . 42–51 . 2007 . 17020792 . 10.1016/j.gene.2006.06.030 .

Notes and References

1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res . 10 . 5 . 703–13 . Aug 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
2. Web site: Entrez Gene: ERGIC3 ERGIC and golgi 3.
3. Zhang. Ling-yun. Liu. Min. Li. Xin. Tang. Hua. miR-490-3p Modulates Cell Growth and Epithelial to Mesenchymal Transition of Hepatocellular Carcinoma Cells by Targeting Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 3 (ERGIC3). Journal of Biological Chemistry. 288. 6. 2013. 4035–4047. 0021-9258. 10.1074/jbc.M112.410506. 3567655. 23212913. free.
4. Lin. Qing-Hai. Zhang. Kui-Dong. Duan. He-Xian. Liu. Min-Xia. Wei. Wan-Li. Cao. Yi. ERGIC3, which is regulated by miR-203a, is a potential biomarker for non-small cell lung cancer. Cancer Science. 106. 10. 2015. 1463–1473. 1347-9032. 10.1111/cas.12741. 4638005. 26177443.