ERG11 explained

Sterol 14-demethylase
Organism:Saccharomyces cerevisiae
Taxid:4932
Symbol:ERG11
Altsymbols:CYP51F1
Entrezgene:856398
Homologene:55488
Refseqmrna:NM_001179137
Refseqprotein:NP_011871
Uniprot:P10614
Ecnumber:1.14.14.154
Chromosome:VIII
Entrezchromosome:NC_001140
Genloc Start:120091
Genloc End:121683

ERG11 or Sterol 14-demethylase is a fungal cytochrome P450 enzyme originally from Saccharomyces cerevisiae, belongs to family CYP51, with the CYP Symbol CYP51F1.[1] ERG11 catalyzes the C14-demethylation of lanosterol to 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first step of biosynthesis of the zymosterol, zymosterol will be further converted into Ergosterol.[2]

Notes and References

  1. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS . 6 . Global analysis of protein expression in yeast . Nature . 425 . 6959 . 737–41 . October 2003 . 14562106 . 10.1038/nature02046 . 2003Natur.425..737G . 4344864 .
  2. Mo C, Bard M . Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex . Journal of Lipid Research . 46 . 9 . 1991–8 . September 2005 . 15995173 . 10.1194/jlr.M500153-JLR200 . free .