ERC1 explained

ELKS/RAB6-interacting/CAST family member 1 is a protein that in humans is encoded by the ERC1 gene.^{[1] [2] [3]} The name ELKS is derived from "protein rich in the amino acids E, L, K and S"^[4]

The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene.^[5] ELKS has been reported to direct vesicles with RAB6A to melanosomes.^[4]

Interactions

ERC1 has been shown to interact with RAB6A.

Further reading

• Nakajima D, Okazaki N, Yamakawa H . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . etal. free .
• Armour JA, Crosier M, Jeffreys AJ . Human minisatellite alleles detectable only after PCR amplification. . Genomics . 12 . 1 . 116–24 . 1992 . 1733848 . 10.1016/0888-7543(92)90413-M .
• Nakata T, Kitamura Y, Shimizu K . Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma. . Genes Chromosomes Cancer . 25 . 2 . 97–103 . 1999 . 10337992 . 10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L . 290489 . etal.
• Kikuno R, Nagase T, Ishikawa K . Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 3 . 197–205 . 1999 . 10470851 . 10.1093/dnares/6.3.197 . etal. free .
• Nakata T, Yokota T, Emi M, Minami S . Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. . Genes Chromosomes Cancer . 35 . 1 . 30–7 . 2002 . 12203787 . 10.1002/gcc.10095 . 21891794 .
• Wang Y, Liu X, Biederer T, Südhof TC . A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 22 . 14464–9 . 2002 . 12391317 . 10.1073/pnas.182532999 . 137906 . 2002PNAS...9914464W . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ko J, Na M, Kim S . Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. . J. Biol. Chem. . 278 . 43 . 42377–85 . 2004 . 12923177 . 10.1074/jbc.M307561200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E . CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST. . Genes Cells . 9 . 1 . 15–23 . 2004 . 14723704 . 10.1111/j.1356-9597.2004.00697.x . 13337267 . etal. free .
• Ducut Sigala JL, Bottero V, Young DB . Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. . Science . 304 . 5679 . 1963–7 . 2004 . 15218148 . 10.1126/science.1098387 . 2004Sci...304.1963D . 29198955 . etal.
• Jin J, Smith FD, Stark C . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . etal. free . 2004CBio...14.1436J .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Yokota T, Nakata T, Minami S, Inazawa J, Emi M . Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma . J Hum Genet . 45 . 1 . 6–11 . Apr 2000 . 10697956 . 10.1007/s100380050002 . free .
2. Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B . Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport . Traffic . 3 . 4 . 289–97 . Apr 2002 . 11929610 . 10.1034/j.1600-0854.2002.030406.x . 22993226 .
3. Web site: Entrez Gene: ERC1 ELKS/RAB6-interacting/CAST family member 1.
4. Patwardhan A, Bardin S, Miserey-Lenkei S, Larue L, Goud B, Raposo G, Delevoye C . Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes . Nature Communications . 8 . 15835 . 2017 . 28607494 . 10.1038/ncomms15835 . 5474736. 2017NatCo...815835P .
5. Web site: Entrez Gene: ERC1 ELKS/RAB6-interacting/CAST family member 1.