ERB-196 explained

ERB-196, also known as WAY-202196, is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ.^{[1] [2] [3] [4] [5] [6]} It possesses 78-fold selectivity for the ERβ over the ERα. The drug was under development by Wyeth for the treatment of inflammation and sepsis starting in 2004 but development was discontinued by 2011.^[7]

See also

• 8β-VE2
• Diarylpropionitrile
• FERb 033
• Prinaberel
• WAY-166818
• WAY-200070
• WAY-214156

External links

• ERB-196 - AdisInsight

Notes and References

1. Book: Manas ES, MewshawRE, Harris HA, Malamas MS. Isoform Specificity: The Design of Estrogen Receptor-β Selective Compounds . Hubbard RE . Structure-based Drug Discovery: An Overview. https://books.google.com/books?id=Q_Kj1Qvgob4C&pg=PA241 . 2006. Royal Society of Chemistry. 978-0-85404-351-4. 241–.
2. Web site: ERB 196 . AdisInsight . Springer Nature Switzerland AG . 15 January 2022 . https://web.archive.org/web/20180625161018/https://adisinsight.springer.com/drugs/800021229 . 25 June 2018 . dead.
3. Book: Acton QA . Estradiol . Estrogens—Advances in Research and Application . 2013 . ScholarlyEditions . https://books.google.com/books?id=NYW4rG83zrUC&pg=PA52. 978-1-4816-8771-3. 52– .
4. Book: Weatherman RV . Untangling the Estrogen Receptor Web: Tools to Selectively Study Estrogen-Binding Receptors . Ottow E, Weinmann H . Nuclear Receptors as Drug Targets. Methods and Principles in Medicinal Chemistry . https://books.google.com/books?id=iATfLbPgRugC&pg=PA66. 8 September 2008. John Wiley & Sons. 978-3-527-62330-3. 66– . 10.1002/9783527623297.ch3 .
5. Mewshaw RE, Edsall RJ, Yang C, Manas ES, Xu ZB, Henderson RA, Keith JC, Harris HA . 6 . ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity . Journal of Medicinal Chemistry . 48 . 12 . 3953–3979 . June 2005 . 15943471 . 10.1021/jm058173s .
6. Cristofaro PA, Opal SM, Palardy JE, Parejo NA, Jhung J, Keith JC, Harris HA . WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock . Critical Care Medicine . 34 . 8 . 2188–2193 . August 2006 . 16755255 . 10.1097/01.CCM.0000227173.13497.56 . 20876539 .
7. Book: Adrie C, Azoulay E, Timsit JF . Influence of Gender on Outcome of Severe Sepsis . Vincent JL . Yearbook of Intensive Care and Emergency Medicine 2007. https://books.google.com/books?id=zT8_AAAAQBAJ&pg=PA891 . 8 December 2007. Springer Science & Business Media. 978-3-540-49433-1. 891–.