ER-X explained

ER-X is a membrane-associated receptor that is bound and activated by 17α-estradiol and 17β-estradiol and is a putative membrane estrogen receptor (mER).[1] [2] [3] It shows sequence homology with ERα and ERβ and activates the MAPK/ERK pathway. The receptor is insensitive to the antiestrogen ICI-182,780 (fulvestrant).

See also

Notes and References

  1. Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, Connolly ES, Nethrapalli IS, Tinnikov AA . 6 . ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury . The Journal of Neuroscience . 22 . 19 . 8391–8401 . October 2002 . 12351713 . 6757764 . 10.1523/JNEUROSCI.22-19-08391.2002 . E. Sander Connolly .
  2. Soltysik K, Czekaj P . Membrane estrogen receptors - is it an alternative way of estrogen action? . Journal of Physiology and Pharmacology . 64 . 2 . 129–142 . April 2013 . 23756388 .
  3. Roepke TA, Ronnekleiv OK, Kelly MJ . Physiological consequences of membrane-initiated estrogen signaling in the brain . Frontiers in Bioscience . 16 . 4 . 1560–1573 . January 2011 . 21196248 . 3094271 . 10.2741/3805 .

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