EPS8L1 explained

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.^{[1] [2]}

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Wan D, Gong Y, Qin W . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . 2004PNAS..10115724W . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Offenhäuser N, Borgonovo A, Disanza A . The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway . Mol. Biol. Cell . 15 . 1 . 91–8 . 2004 . 14565974 . 10.1091/mbc.E03-06-0427 . 307530 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Wu K, Xu Z, Wang M . [Cloning and expression analyses of down-regulated cDNA C6-2A in human esophageal cancer] . Zhonghua Yi Xue Yi Chuan Xue Za Zhi . 16 . 5 . 325–7 . 1999 . 10514543 . etal.

Notes and References

1. Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C . In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure . Genomics . 81 . 2 . 234–44 . Mar 2003 . 12620401 . 10.1016/S0888-7543(03)00002-8 .
2. Web site: Entrez Gene: EPS8L1 EPS8-like 1.