EPS15L1 explained

Epidermal growth factor receptor substrate 15-like 1 is a protein that in humans is encoded by the EPS15L1 gene.^[1]

Interactions

EPS15L1 has been shown to interact with HRB.^[2]

References

• Umair M, Ullah A, Abbas S, Ahmad F, Basit S, Ahmad W . First direct evidence of involvement of a homozygous loss-of-function variant in the EPS15L1 gene underlying split-hand/split-foot malformation . Clin Genet . 93 . 3 . 699–702 . 2018 . 29023680 . 10.1111/cge.13152 . free .

Further reading

• Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP . Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module . Genes Dev. . 11 . 17 . 2239–49 . 1997 . 9303539 . 275390 . 10.1101/gad.11.17.2239 .
• Carbone R, Fré S, Iannolo G, Belleudi F, Mancini P, Pelicci PG, Torrisi MR, Di Fiore PP . eps15 and eps15R are essential components of the endocytic pathway . Cancer Res. . 57 . 24 . 5498–504 . 1997 . 9407958 .
• Coda L, Salcini AE, Confalonieri S, Pelicci G, Sorkina T, Sorkin A, Pelicci PG, Di Fiore PP . Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization . J. Biol. Chem. . 273 . 5 . 3003–12 . 1998 . 9446614 . 10.1074/jbc.273.5.3003 . free .
• Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P . Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis . Nature . 394 . 6695 . 793–7 . 1998 . 9723620 . 10.1038/29555 . 1998Natur.394..793C . 4430975 .
• Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M . Selection system for genes encoding nuclear-targeted proteins . Nat. Biotechnol. . 16 . 13 . 1338–42 . 1998 . 9853615 . 10.1038/4315 . 20001769 .
• Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP . The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport . J. Cell Biol. . 147 . 7 . 1379–84 . 1999 . 10613896 . 2174238 . 10.1083/jcb.147.7.1379 .
• Offenhäuser N, Santolini E, Simeone A, Di Fiore PP . Differential patterns of expression of Eps15 and Eps15R during mouse embryogenesis . Mech. Dev. . 95 . 1–2 . 309–12 . 2000 . 10906484 . 10.1016/S0925-4773(00)00363-4 . 17472161 . free .
• Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS . Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery . J. Cell Biol. . 153 . 5 . 1111–20 . 2001 . 11381094 . 2174325 . 10.1083/jcb.153.5.1111 .
• Poupon V, Polo S, Vecchi M, Martin G, Dautry-Varsat A, Cerf-Bensussan N, Di Fiore PP, Benmerah A . Differential nucleocytoplasmic trafficking between the related endocytic proteins Eps15 and Eps15R . J. Biol. Chem. . 277 . 11 . 8941–8 . 2002 . 11777906 . 10.1074/jbc.M108385200 . free .
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Schmid EM, Ford MG, Burtey A, Praefcke GJ, Peak-Chew SY, Mills IG, Benmerah A, McMahon HT . Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly . PLOS Biol. . 4 . 9 . e262 . 2006 . 16903783 . 1540706 . 10.1371/journal.pbio.0040262 . free .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Web site: Entrez Gene: EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1.
2. Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP . The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport . J. Cell Biol. . 147 . 7 . 1379–84 . Dec 1999 . 10613896 . 2174238 . 10.1083/jcb.147.7.1379 .