EPS15 explained

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.[1]

Function

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]

Interactions

EPS15 has been shown to interact with:

Further reading

Notes and References

  1. Wong WT, Kraus MH, Carlomagno F, Zelano A, Druck T, Croce CM, Huebner K, Di Fiore PP . The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32 . Oncogene . 9 . 6 . 1591–7 . Jun 1994 . 8183552 .
  2. Web site: Entrez Gene: EPS15 epidermal growth factor receptor pathway substrate 15.
  3. Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH, Hanafusa H . The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R . J. Biol. Chem. . 270 . 25 . 15341–7 . June 1995 . 7797522 . 10.1074/jbc.270.25.15341. free .
  4. Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P . Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis . Nature . 394 . 6695 . 793–7 . August 1998 . 9723620 . 10.1038/29555 . 1998Natur.394..793C . 4430975 .
  5. Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y . Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15 . J. Biol. Chem. . 275 . 20 . 15271–8 . May 2000 . 10809762 . 10.1074/jbc.275.20.15271. free .
  6. Bache KG, Raiborg C, Mehlum A, Stenmark H . STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes . J. Biol. Chem. . 278 . 14 . 12513–21 . April 2003 . 12551915 . 10.1074/jbc.M210843200 . free .
  7. Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP . The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport . J. Cell Biol. . 147 . 7 . 1379–84 . December 1999 . 10613896 . 2174238 . 10.1083/jcb.147.7.1379.
  8. Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A . Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors . EMBO J. . 18 . 13 . 3629–42 . July 1999 . 10393179 . 1171441 . 10.1093/emboj/18.13.3629 .