EPPE-holin family explained

The Erwinia Phage Phi-Ea1h Holin (EPPE-Hol) Family (TC# 1.E.58) consists of a single protein, holin of Erwinia Phage Phi-Ea1h (TC# 1.E.58.1.1), which is 119 amino acyl residues in length and exhibits a single transmembrane segment (TMS). Out of three open reading frames sequenced from bacteriophage Phi-Ea1h, the second ORF encodes this holin.^[1] Kim and Geider found that no signal sequence was observed at the N-terminus of the enzyme and suggested that the holin possibly facilities the export of an which may export a lysozyme and EPS depolymerase that carries out extracellular polysaccharide (EPS)-degrading activity.^[2]

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• Reddy . Bhaskara L. . Saier Jr . Milton H. . 2013 . Topological and phylogenetic analyses of bacterial holin families and superfamilies . Biochimica et Biophysica Acta (BBA) - Biomembranes . 1828 . 11. 2654–2671 . 10.1016/j.bbamem.2013.07.004 . 23856191 . 3788059 .
• Saier . Milton H. . Reddy . Bhaskara L. . 2015 . Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications . Journal of Bacteriology . 197 . 1. 7–17 . 10.1128/JB.02046-14 . 25157079 . 4288690 .
• Wang . I. N. . Smith . D. L. . Young . R. . 2000 . Holins: the protein clocks of bacteriophage infections . Annual Review of Microbiology . 54 . 799–825 . 10.1146/annurev.micro.54.1.799 . 11018145 .

Notes and References

1. Kim. W. S.. Geider. K.. 2000-11-01. Characterization of a Viral EPS-Depolymerase, a Potential Tool for Control of Fire Blight. Phytopathology. 90. 11. 1263–1268. 10.1094/PHYTO.2000.90.11.1263. 0031-949X. 18944430. free.
2. Web site: 1.E.58. The Erwinia Phage Phi-Ea1h Holin (EPPE-Hol) Family. TCDB. 2016-03-29.