EPN2 explained

Epsin-2 is a protein that in humans is encoded by the EPN2 gene.^{[1] [2]}

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

Further reading

• Salcini AE, Confalonieri S, Doria M . Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module . Genes Dev. . 11 . 17 . 2239–49 . 1997 . 9303539 . 10.1101/gad.11.17.2239 . 275390 . etal.
• Yamabhai M, Hoffman NG, Hardison NL . Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains . J. Biol. Chem. . 273 . 47 . 31401–7 . 1998 . 9813051 . 10.1074/jbc.273.47.31401 . etal. free .
• Kikuno R, Nagase T, Ishikawa K . Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 6 . 3 . 197–205 . 1999 . 10470851 . 10.1093/dnares/6.3.197 . etal. free .
• Ford MG, Mills IG, Peter BJ . Curvature of clathrin-coated pits driven by epsin . Nature . 419 . 6905 . 361–6 . 2002 . 12353027 . 10.1038/nature01020 . 2002Natur.419..361F . 4372368 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Hussain NK, Yamabhai M, Bhakar AL . A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding . J. Biol. Chem. . 278 . 31 . 28823–30 . 2003 . 12750376 . 10.1074/jbc.M300995200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Colland F, Jacq X, Trouplin V . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . etal.
• Jin J, Smith FD, Stark C . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . etal. free . 2004CBio...14.1436J .
• Ballif BA, Villén J, Beausoleil SA . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . etal. free .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P . The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module . J Biol Chem . 274 . 48 . 33959–65 . Dec 1999 . 10567358 . 10.1074/jbc.274.48.33959 . free .
2. Web site: Entrez Gene: EPN2 epsin 2.