EPN1 explained

Epsin-1 is a protein that in humans is encoded by the EPN1 gene.^{[1] [2] [3]}

EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM]

Interactions

EPN1 has been shown to interact with REPS2, AP2A2 and EPS15.^[1]

Further reading

• Drake MT, Downs MA, Traub LM . Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites . J. Biol. Chem. . 275 . 9 . 6479–89 . 2000 . 10692452 . 10.1074/jbc.275.9.6479 . 22584410 . free .
• Kariya K . Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation . J. Biol. Chem. . 275 . 24 . 18399–406 . 2000 . 10764745 . 10.1074/jbc.M000521200 . vanc. Koyama S . Nakashima S . 3 . Oshiro . T . Morinaka . K . Kikuchi . A . free.
• Hyman J . Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf) . J. Cell Biol. . 149 . 3 . 537–46 . 2000 . 10791968 . 10.1083/jcb.149.3.537 . 2174850 . vanc. Chen H . Di Fiore PP . 3 . De Camilli . P . Brunger . AT .
• Drake MT, Traub LM . Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller . J. Biol. Chem. . 276 . 31 . 28700–9 . 2001 . 11382783 . 10.1074/jbc.M104226200 . free .
• Ford MG . Curvature of clathrin-coated pits driven by epsin . Nature . 419 . 6905 . 361–6 . 2002 . 12353027 . 10.1038/nature01020 . vanc. Mills IG . Peter BJ . 3 . Vallis . Yvonne . Praefcke . Gerrit J. K. . Evans . Philip R. . McMahon . Harvey T. . 2002Natur.419..361F . 4372368 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Koshiba S, Kigawa T, Kikuchi A, Yokoyama S . Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin . J. Struct. Funct. Genomics . 2 . 1 . 1–8 . 2003 . 12836669 . 10.1023/A:1011397007366 . 13317798 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Timsit YE, Miller SL, Mohney RP, O'Bryan JP . The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin . Biochem. Biophys. Res. Commun. . 328 . 2 . 550–9 . 2005 . 15694383 . 10.1016/j.bbrc.2005.01.022 .
• Schmid EM . Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly . PLOS Biol. . 4 . 9 . e262 . 2007 . 16903783 . 10.1371/journal.pbio.0040262 . 1540706 . vanc. Ford MG . Burtey A . 3 . Praefcke . Gerrit J. K. . Peak-Chew . Sew-Yeu . Mills . Ian G. . Benmerah . Alexandre . McMahon . Harvey T. . free .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.

Notes and References

1. Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P . Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis . Nature . 394 . 6695 . 793–7 . Sep 1998 . 9723620 . 10.1038/29555 . 1998Natur.394..793C . 4430975 .
2. Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A . Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis . Oncogene . 18 . 43 . 5915–22 . Dec 1999 . 10557078 . 10.1038/sj.onc.1202974 . free .
3. Web site: Entrez Gene: EPN1 epsin 1.