EPHB6 explained

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.^[1]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

Further reading

• Flanagan JG, Vanderhaeghen P . The ephrins and Eph receptors in neural development . Annu. Rev. Neurosci. . 21 . 309–45 . 1998 . 9530499 . 10.1146/annurev.neuro.21.1.309 .
• Zhou R . The Eph family receptors and ligands . Pharmacol. Ther. . 77 . 3 . 151–81 . 1998 . 9576626 . 10.1016/S0163-7258(97)00112-5 .
• Holder N, Klein R . Eph receptors and ephrins: effectors of morphogenesis . Development . 126 . 10 . 2033–44 . 1999 . 10.1242/dev.126.10.2033 . 10207129 .
• Wilkinson DG . Eph receptors and ephrins: regulators of guidance and assembly; Chapter: Eph receptors and ephrins: Regulators of guidance and assembly . Int. Rev. Cytol. . 196 . 177–244 . 2000 . 10730216 . 10.1016/S0074-7696(00)96005-4 . International Review of Cytology . 978-0-12-364600-2 .
• Xu Q, Mellitzer G, Wilkinson DG . Roles of Eph receptors and ephrins in segmental patterning . Philos. Trans. R. Soc. Lond. B Biol. Sci. . 355 . 1399 . 993–1002 . 2001 . 11128993 . 10.1098/rstb.2000.0635 . 1692797 .
• Wilkinson DG . Multiple roles of EPH receptors and ephrins in neural development . Nat. Rev. Neurosci. . 2 . 3 . 155–64 . 2001 . 11256076 . 10.1038/35058515 . 205014301 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Matsuoka H, Iwata N, Ito M . Expression of a kinase-defective Eph-like receptor in the normal human brain . Biochem. Biophys. Res. Commun. . 235 . 3 . 487–92 . 1997 . 9207182 . 10.1006/bbrc.1997.6812 . etal. 20.500.14094/D1001814 . free .
• Ephnomenclaturecommittee. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee . Cell . 90 . 3 . 403–4 . 1997 . 9267020 . 10.1016/S0092-8674(00)80500-0 . 26773768 . free .
• Hock B, Böhme B, Karn T . PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor . Proc. Natl. Acad. Sci. U.S.A. . 95 . 17 . 9779–84 . 1998 . 9707552 . 10.1073/pnas.95.17.9779 . 21413 . 1998PNAS...95.9779H . etal. free .
• Munthe E, Rian E, Holien T . Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6 . FEBS Lett. . 466 . 1 . 169–74 . 2000 . 10648835 . 10.1016/S0014-5793(99)01793-7 . 40328521 . etal. free .
• Shimoyama M, Matsuoka H, Tamekane A . T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells . Growth Factors . 18 . 1 . 63–78 . 2000 . 10831073 . 10.3109/08977190009003234 . 9397812 . etal. 20.500.14094/D1002141 . free .
• Tang XX, Zhao H, Robinson ME . Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma . Proc. Natl. Acad. Sci. U.S.A. . 97 . 20 . 10936–41 . 2000 . 10984508 . 10.1073/pnas.190123297 . 27127 . 2000PNAS...9710936T . etal. free .
• Luo H, Wan X, Wu Y, Wu J . Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells . J. Immunol. . 167 . 3 . 1362–70 . 2001 . 11466354 . 10.4049/jimmunol.167.3.1362. free .

Notes and References

1. Web site: Entrez Gene: EPHB6 EPH receptor B6.