EPH receptor B1 explained

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.^{[1] [2]}

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[2]

Interactions

EPH receptor B1 has been shown to interact with:

• ACP1^[3]
• GRB7^[4] and
• NCK1^[5]
• Ephrin-B2^[6]

Further reading

• Flanagan JG, Vanderhaeghen P . The ephrins and Eph receptors in neural development . Annu. Rev. Neurosci. . 21 . 309–45 . 1998 . 9530499 . 10.1146/annurev.neuro.21.1.309 .
• Zhou R . The Eph family receptors and ligands . Pharmacol. Ther. . 77 . 3 . 151–81 . 1998 . 9576626 . 10.1016/S0163-7258(97)00112-5 .
• Abrahamson DR, Robert B, Hyink DP, St John PL, Daniel TO . Origins and formation of microvasculature in the developing kidney . Kidney Int. Suppl. . 67 . S7-11 . 1998 . 9736245 . 10.1046/j.1523-1755.1998.06702.x . free .
• Holder N, Klein R . Eph receptors and ephrins: effectors of morphogenesis . Development . 126 . 10 . 2033–44 . 1999 . 10.1242/dev.126.10.2033 . 10207129 .
• Wilkinson DG . Eph receptors and ephrins: regulators of guidance and assembly . Int. Rev. Cytol. . 196 . 177–244 . 2000 . 10730216 . 10.1016/S0074-7696(00)96005-4 . International Review of Cytology . 9780123646002 .
• Xu Q, Mellitzer G, Wilkinson DG . Roles of Eph receptors and ephrins in segmental patterning . Philos. Trans. R. Soc. Lond. B Biol. Sci. . 355 . 1399 . 993–1002 . 2000 . 11128993 . 1692797 . 10.1098/rstb.2000.0635 .
• Wilkinson DG . Multiple roles of EPH receptors and ephrins in neural development . Nat. Rev. Neurosci. . 2 . 3 . 155–64 . 2001 . 11256076 . 10.1038/35058515 . 205014301 .
• Larose L, Gish G, Shoelson S, Pawson T . Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1 . Oncogene . 8 . 9 . 2493–9 . 1993 . 7689724 .
• Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD . Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity . Science . 266 . 5186 . 816–9 . 1994 . 7973638 . 10.1126/science.7973638 . 1994Sci...266..816D .
• Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E . Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors . EMBO J. . 13 . 16 . 3757–62 . 1994 . 8070404 . 395287 . 10.1002/j.1460-2075.1994.tb06685.x.
• Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ . Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases . Mol. Immunol. . 32 . 16 . 1197–205 . 1995 . 8559144 . 10.1016/0161-5890(95)00108-5 .
• Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD . Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis . Neuron . 17 . 1 . 9–19 . 1996 . 8755474 . 10.1016/S0896-6273(00)80276-7 . 1075856 . free .
• Stein E, Cerretti DP, Daniel TO . Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells . J. Biol. Chem. . 271 . 38 . 23588–93 . 1996 . 8798570 . 10.1074/jbc.271.38.23588 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK . LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain . Cytokine . 9 . 8 . 540–9 . 1997 . 9245480 . 10.1006/cyto.1997.0199 .
• Ephnomenclaturecommittee . Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee . Cell . 90 . 3 . 403–4 . 1997 . 9267020 . 10.1016/S0092-8674(00)80500-0 . 26773768 . free .
• Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO . Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase . J. Biol. Chem. . 273 . 3 . 1303–8 . 1998 . 9430661 . 10.1074/jbc.273.3.1303 . free .
• Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO . Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses . Genes Dev. . 12 . 5 . 667–78 . 1998 . 9499402 . 316584 . 10.1101/gad.12.5.667 .

Notes and References

1. Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N . cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain . Genomics . 29 . 2 . 426–37 . 1995 . 8666391 . 10.1006/geno.1995.9985 . free .
2. Web site: Entrez Gene: EPHB1 EPH receptor B1.
3. Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO . Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses . Genes Dev. . 12 . 5 . 667–78 . Mar 1998 . 9499402 . 316584 . 10.1101/gad.12.5.667.
4. Han DC, Shen TL, Miao H, Wang B, Guan JL . EphB1 associates with Grb7 and regulates cell migration . J. Biol. Chem. . 277 . 47 . 45655–61 . Nov 2002 . 12223469 . 10.1074/jbc.M203165200 . free .
5. Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO . Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase . J. Biol. Chem. . 273 . 3 . 1303–8 . Jan 1998 . 9430661 . 10.1074/jbc.273.3.1303. free .
6. Williams. SE. Mann. F . Erskine. L. 2003. Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. . Neuron. 39. 6 . 919–935. 10.1016/j.neuron.2003.08.017. 12971893 . 18565204. free.