EPHA7 explained

Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene.^{[1] [2]}

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Further reading

• Flanagan JG, Vanderhaeghen P . The ephrins and Eph receptors in neural development . Annu. Rev. Neurosci. . 21 . 309–45 . 1998 . 9530499 . 10.1146/annurev.neuro.21.1.309 .
• Zhou R . The Eph family receptors and ligands . Pharmacol. Ther. . 77 . 3 . 151–81 . 1998 . 9576626 . 10.1016/S0163-7258(97)00112-5 .
• Holder N, Klein R . Eph receptors and ephrins: effectors of morphogenesis . Development . 126 . 10 . 2033–44 . 1999 . 10.1242/dev.126.10.2033 . 10207129 .
• Wilkinson DG . Eph receptors and ephrins: regulators of guidance and assembly . Int. Rev. Cytol. . 196 . 177–244 . 2000 . 10730216 . 10.1016/S0074-7696(00)96005-4 . International Review of Cytology . 978-0-12-364600-2 .
• Xu Q, Mellitzer G, Wilkinson DG . Roles of Eph receptors and ephrins in segmental patterning . Philos. Trans. R. Soc. Lond. B Biol. Sci. . 355 . 1399 . 993–1002 . 2001 . 11128993 . 10.1098/rstb.2000.0635 . 1692797 .
• Wilkinson DG . Multiple roles of EPH receptors and ephrins in neural development . Nat. Rev. Neurosci. . 2 . 3 . 155–64 . 2001 . 11256076 . 10.1038/35058515 . 205014301 .
• Fox GM, Holst PL, Chute HT . cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases . Oncogene . 10 . 5 . 897–905 . 1995 . 7898931 . etal.
• Gale NW, Holland SJ, Valenzuela DM . Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis . Neuron . 17 . 1 . 9–19 . 1996 . 8755474 . 10.1016/S0896-6273(00)80276-7 . 1075856 . etal. free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Ciossek T, Ullrich A . Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1 . Oncogene . 14 . 1 . 35–43 . 1997 . 9010230 . 10.1038/sj.onc.1200800 . 24727040 .
• Hock B, Böhme B, Karn T . PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor . Proc. Natl. Acad. Sci. U.S.A. . 95 . 17 . 9779–84 . 1998 . 9707552 . 10.1073/pnas.95.17.9779 . 21413 . 1998PNAS...95.9779H . etal. free .
• Bianchi LM, Liu H . Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear . Anat. Rec. . 254 . 1 . 127–34 . 1999 . 9892426 . 10.1002/(SICI)1097-0185(19990101)254:1<127::AID-AR16>3.0.CO;2-Q . free .
• Janis LS, Cassidy RM, Kromer LF . Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum . J. Neurosci. . 19 . 12 . 4962–71 . 1999 . 10366629 . 10.1523/JNEUROSCI.19-12-04962.1999. 6782661 .
• Stubbs J, Palmer A, Vidovic M, Marotte LR . Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection . Eur. J. Neurosci. . 12 . 10 . 3626–36 . 2000 . 11029633 . 10.1046/j.1460-9568.2000.00251.x . 37988439 .

Notes and References

1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee . Cell . 90 . 3 . 403–4 . Sep 1997 . 9267020 . 10.1016/S0092-8674(00)80500-0 . Ephnomenclaturecommittee . 26773768 . free .
2. Web site: Entrez Gene: EPHA7 EPH receptor A7.