EPH receptor A1 explained

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.^{[1] [2]}

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.^[2]

Further reading

• Flanagan JG, Vanderhaeghen P . The ephrins and Eph receptors in neural development. . Annu. Rev. Neurosci. . 21 . 309–45 . 1998 . 9530499 . 10.1146/annurev.neuro.21.1.309 .
• Zhou R . The Eph family receptors and ligands. . Pharmacol. Ther. . 77 . 3 . 151–81 . 1998 . 9576626 . 10.1016/S0163-7258(97)00112-5.
• Holder N, Klein R . Eph receptors and ephrins: effectors of morphogenesis. . Development . 126 . 10 . 2033–44 . 1999 . 10.1242/dev.126.10.2033 . 10207129 .
• Wilkinson DG . Eph receptors and ephrins: regulators of guidance and assembly. . Int. Rev. Cytol. . 196 . 177–244 . 2000 . 10730216 . 10.1016/S0074-7696(00)96005-4. International Review of Cytology . 9780123646002 .
• Xu Q, Mellitzer G, Wilkinson DG . Roles of Eph receptors and ephrins in segmental patterning. . Philos. Trans. R. Soc. Lond. B Biol. Sci. . 355 . 1399 . 993–1002 . 2001 . 11128993 . 1692797 . 10.1098/rstb.2000.0635 .
• Wilkinson DG . Multiple roles of EPH receptors and ephrins in neural development. . Nat. Rev. Neurosci. . 2 . 3 . 155–64 . 2001 . 11256076 . 10.1038/35058515. 205014301 .
• Hirai H, Maru Y, Hagiwara K . A novel putative tyrosine kinase receptor encoded by the eph gene. . Science . 238 . 4834 . 1717–20 . 1988 . 2825356 . 10.1126/science.2825356 . etal.
• Gale NW, Holland SJ, Valenzuela DM . Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. . Neuron . 17 . 1 . 9–19 . 1996 . 8755474 . 10.1016/S0896-6273(00)80276-7. 1075856 . etal. free .
• Owshalimpur D, Kelley MJ . Genomic structure of the EPHA1 receptor tyrosine kinase gene. . Mol. Cell. Probes . 13 . 3 . 169–73 . 1999 . 10369740 . 10.1006/mcpr.1999.0228 .
• Kalo MS, Pasquale EB . Signal transfer by eph receptors . Cell and Tissue Research. 298 . 1 . 1–9 . October 1999. 10502115 . 10.1007/pl00008807. 1241074 .
• Coulthard MG, Lickliter JD, Subanesan N . Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues. . Growth Factors . 18 . 4 . 303–17 . 2002 . 11519828 . 10.3109/08977190109029118 . 43039239 . etal.
• Hillier LW, Fulton RS, Fulton LA . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . etal. free .
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.

Notes and References

1. Ephnomenclaturecommittee. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee . Cell . 90 . 3 . 403–4 . Sep 1997 . 9267020 . 10.1016/S0092-8674(00)80500-0. 26773768 . free .
2. Web site: Entrez Gene: EPHA1 EPH receptor A1.