EP400 explained

E1A-binding protein p400 is a protein that in humans is encoded by the EP400 gene.^{[1] [2] [3]}

Interactions

EP400 has been shown to interact with Transformation/transcription domain-associated protein, RuvB-like 1^[2] and Myc.^[2]

Further reading

• Doyon Y, Côté J . The highly conserved and multifunctional NuA4 HAT complex. . Curr. Opin. Genet. Dev. . 14 . 2 . 147–54 . 2004 . 15196461 . 10.1016/j.gde.2004.02.009 .
• Nagase T, Kikuno R, Ishikawa K . Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 2 . 143–50 . 2000 . 10819331 . 10.1093/dnares/7.2.143 . etal. free .
• Nagase T, Nakayama M, Nakajima D . Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 8 . 2 . 85–95 . 2001 . 11347906 . 10.1093/dnares/8.2.85 . etal. free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Cai Y, Jin J, Tomomori-Sato C . Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. . J. Biol. Chem. . 278 . 44 . 42733–6 . 2003 . 12963728 . 10.1074/jbc.C300389200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Doyon Y, Selleck W, Lane WS . Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. . Mol. Cell. Biol. . 24 . 5 . 1884–96 . 2004 . 14966270 . 10.1128/MCB.24.5.1884-1896.2004 . 350560 . etal.
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Chan HM, Narita M, Lowe SW, Livingston DM . The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. . Genes Dev. . 19 . 2 . 196–201 . 2005 . 15655109 . 10.1101/gad.1280205 . 545875 .
• Samuelson AV, Narita M, Chan HM . p400 is required for E1A to promote apoptosis. . J. Biol. Chem. . 280 . 23 . 21915–23 . 2005 . 15741165 . 10.1074/jbc.M414564200 . etal. free .
• Tyteca S, Vandromme M, Legube G . Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. . EMBO J. . 25 . 8 . 1680–9 . 2006 . 16601686 . 10.1038/sj.emboj.7601066 . 1440826 . etal.

Notes and References

1. Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA . cDNAs with long CAG trinucleotide repeats from human brain . Hum Genet . 100 . 1 . 114–22 . Jul 1997 . 9225980 . 10.1007/s004390050476 . 25999127 .
2. Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM . The p400 complex is an essential E1A transformation target . Cell . 106 . 3 . 297–307 . Aug 2001 . 11509179 . 10.1016/S0092-8674(01)00450-0 . 15634637 . free .
3. Web site: Entrez Gene: EP400 E1A binding protein p400.