ENTPD6 explained

Ectonucleoside triphosphate diphosphohydrolase 6 is an enzyme that in humans is encoded by the ENTPD6 gene.^{[1] [2]}

Function

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions, which is characteristic of NTPases.

Further reading

• Chadwick BP, Frischauf AM . Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes . Mammalian Genome . 8 . 9 . 668–72 . Sep 1997 . 9271669 . 10.1007/s003359900534 . 42644202 .
• Hicks-Berger CA, Chadwick BP, Frischauf AM, Kirley TL . Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2) . The Journal of Biological Chemistry . 275 . 44 . 34041–5 . Nov 2000 . 10948193 . 10.1074/jbc.M004723200 . free .
• Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE . CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart . Biochemistry . 39 . 42 . 12916–23 . Oct 2000 . 11041856 . 10.1021/bi000959z .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . Nov 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Ivanenkov VV, Murphy-Piedmonte DM, Kirley TL . Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function . Biochemistry . 42 . 40 . 11726–35 . Oct 2003 . 14529283 . 10.1021/bi035137r .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . Oct 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Research . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Research . 34 . Database issue . D415-8 . Jan 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Chadwick BP, Frischauf AM . The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster . Genomics . 50 . 3 . 357–67 . Jun 1998 . 9676430 . 10.1006/geno.1998.5317 .
2. Web site: Entrez Gene: ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative function).