ENTPD3 explained

Ectonucleoside triphosphate diphosphohydrolase 3 is an enzyme that in humans is encoded by the ENTPD3 gene.^{[1] [2]}

ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.^[3]

Further reading

• Munkonda MN, Kauffenstein G, Kukulski F . Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists. . Biochem. Pharmacol. . 74 . 10 . 1524–34 . 2007 . 17727821 . 10.1016/j.bcp.2007.07.033 . etal.
• Ivanenkov VV, Meller J, Kirley TL . Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling. . Biochemistry . 44 . 25 . 8998–9012 . 2005 . 15966724 . 10.1021/bi047487z .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Yang F, Hicks-Berger CA, Smith TM, Kirley TL . Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions. . Biochemistry . 40 . 13 . 3943–50 . 2001 . 11300774 . 10.1021/bi002711f .
• Smith TM, Lewis Carl SA, Kirley TL . Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase. . Biochemistry . 38 . 18 . 5849–57 . 1999 . 10231536 . 10.1021/bi990171k .
• Smith TM, Kirley TL . Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1. . Biochim. Biophys. Acta . 1386 . 1 . 65–78 . 1998 . 9675246 . 10.1016/s0167-4838(98)00063-6.
• Chadwick BP, Frischauf AM . Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes. . Mamm. Genome . 8 . 9 . 668–72 . 1997 . 9271669 . 10.1007/s003359900534 . 42644202 .

Notes and References

1. Chadwick BP, Frischauf AM . The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster . Genomics . 50 . 3 . 357–67 . Oct 1998 . 9676430 . 10.1006/geno.1998.5317 .
2. Web site: Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3.
3. Web site: Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3.