Endo-beta-n-acetylglucosaminidase explained

Endo-beta-N-acetylglucosaminidase is a protein that in humans is encoded by the ENGASE gene.^[1]

Function

This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012].

Further reading

• Suzuki T, Yano K, Sugimoto S, Kitajima K, Lennarz WJ, Inoue S, Inoue Y, Emori Y . Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol . Proc. Natl. Acad. Sci. U.S.A. . 99 . 15 . 9691–6 . July 2002 . 12114544 . 124980 . 10.1073/pnas.152333599 . 2002PNAS...99.9691S . free .
• Ortutay Z, Polgár A, Gömör B, Géher P, Lakatos T, Glant TT, Gay RE, Gay S, Pállinger E, Farkas C, Farkas E, Tóthfalusi L, Kocsis K, Falus A, Buzás EI . Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion . Arthritis Rheum. . 48 . 8 . 2163–72 . August 2003 . 12905469 . 10.1002/art.11093 .
• Butkinaree C, Cheung WD, Park S, Park K, Barber M, Hart GW . Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis . J. Biol. Chem. . 283 . 35 . 23557–66 . August 2008 . 18586680 . 2527095 . 10.1074/jbc.M804116200 . free .
• Dorfmueller HC, van Aalten DM . Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds . FEBS Lett. . 584 . 4 . 694–700 . February 2010 . 20026047 . 2828546 . 10.1016/j.febslet.2009.12.020 .
• Park K, Saudek CD, Hart GW . Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes . Diabetes . 59 . 7 . 1845–50 . July 2010 . 20413512 . 2889787 . 10.2337/db09-1086 .
• Chantret I, Fasseu M, Zaoui K, Le Bizec C, Sadou Yayé H, Dupré T, Moore SE . Identification of roles for peptide: N-glycanase and endo-beta-N-acetylglucosaminidase (Engase1p) during protein N-glycosylation in human HepG2 cells . PLOS ONE . 5 . 7 . e11734 . July 2010 . 20668520 . 2909182 . 10.1371/journal.pone.0011734 . 2010PLoSO...511734C . free .
• Xiao F, Zheng X, Cui M, Shi G, Chen X, Li R, Song Z, Rudolph KL, Chen B, Ju Z . Telomere dysfunction-related serological markers are associated with type 2 diabetes . Diabetes Care . 34 . 10 . 2273–8 . October 2011 . 21873561 . 3177723 . 10.2337/dc10-2431 .

Notes and References

1. Web site: Entrez Gene: Endo-beta-N-acetylglucosaminidase. 2018-08-24.