EMR3 explained

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene.[1] [2] EMR3 is a member of the adhesion GPCR family.[3] [4] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[6] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[7] Mice, next to Emr2, lack the Emr3 gene.[8]

Function

The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[9]

Ligands

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.[7]

External links

Notes and References

  1. Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ . Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils . The Journal of Biological Chemistry . 276 . 22 . 18863–18870 . June 2001 . 11279179 . 10.1074/jbc.M101147200 . free .
  2. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB . International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors . Pharmacological Reviews . 67 . 2 . 338–367 . April 2015 . 25713288 . 4394687 . 10.1124/pr.114.009647 .
  3. Book: Stacey M, Yona S . Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
  4. Langenhan T, Aust G, Hamann J . Sticky signaling--adhesion class G protein-coupled receptors take the stage . Science Signaling . 6 . 276 . re3 . May 2013 . 23695165 . 10.1126/scisignal.2003825 . 6958640 .
  5. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT . A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . The EMBO Journal . 31 . 6 . 1364–1378 . March 2012 . 22333914 . 3321182 . 10.1038/emboj.2012.26 .
  6. Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J . The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes . Journal of Leukocyte Biology . 81 . 2 . 440–448 . February 2007 . 17108056 . 10.1189/jlb.0406276 . 37679823 . free .
  7. Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ . Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils . The Journal of Biological Chemistry . 276 . 22 . 18863–18870 . June 2001 . 11279179 . 10.1074/jbc.M101147200 . free .
  8. Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J . An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2 . FASEB Journal . 20 . 14 . 2582–2584 . December 2006 . 17068111 . 10.1096/fj.06-6500fje . 16254868 . free .
  9. Web site: Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3.

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