EMR3 explained

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene.[1] [2] EMR3 is a member of the adhesion GPCR family.[3] [4] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[6] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[7] Mice, next to Emr2, lack the Emr3 gene.[8]

Function

The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[9]

Ligands

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.[7]

External links

Notes and References

  1. Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ . Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils . The Journal of Biological Chemistry . 276 . 22 . 18863–70 . Jun 2001 . 11279179 . 10.1074/jbc.M101147200 . free .
  2. Hamann. J. Aust. G. Araç. D. Engel. FB. Formstone. C. Fredriksson. R. Hall. RA. Harty. BL. Kirchhoff. C. Knapp. B. Krishnan. A. Liebscher. I. Lin. HH. Martinelli. DC. Monk. KR. Peeters. MC. Piao. X. Prömel. S. Schöneberg. T. Schwartz. TW. Singer. K. Stacey. M. Ushkaryov. YA. Vallon. M. Wolfrum. U. Wright. MW. Xu. L. Langenhan. T. Schiöth. HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.. Pharmacological Reviews. April 2015. 67. 2. 338–67. 25713288. 10.1124/pr.114.009647. 4394687.
  3. Book: Stacey M, Yona S . Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
  4. Langenhan. T. Aust. G. Hamann. J. Sticky signaling--adhesion class G protein-coupled receptors take the stage.. Science Signaling. 21 May 2013. 6. 276. re3. 23695165. 10.1126/scisignal.2003825. 6958640.
  5. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT . A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . The EMBO Journal . 31 . 6 . 1364–78 . Mar 2012 . 22333914 . 3321182 . 10.1038/emboj.2012.26 .
  6. Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J . The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes . Journal of Leukocyte Biology . 81 . 2 . 440–8 . Feb 2007 . 17108056 . 10.1189/jlb.0406276 . 37679823 . free .
  7. Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ . Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils . The Journal of Biological Chemistry . 276 . 22 . 18863–70 . Jun 2001 . 11279179 . 10.1074/jbc.M101147200 . free .
  8. Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J . An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2 . FASEB Journal . 20 . 14 . 2582–4 . Dec 2006 . 17068111 . 10.1096/fj.06-6500fje . 16254868 . free .
  9. Web site: Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3.

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