EME (2,5-diethoxy-4-methoxyamphetamine) is a lesser-known psychedelic drug. It is a diethoxy-methoxy analog of TMA-2. EME was first synthesized by Alexander Shulgin. In his book PiHKAL, both the dosage and duration are unknown.[1] EME produces few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of EME.