EMCN explained

Endomucin is a protein that in humans is encoded by the EMCN gene.^{[1] [2] [3]} Endomucin is a marker for endothelial cells^[4] and hematopoietic stem cells.^[5]

Function

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.^[3]

Further reading

• Li G, Miles A, Line A, Rees RC . Identification of tumour antigens by serological analysis of cDNA expression cloning . Cancer Immunology, Immunotherapy . 53 . 3 . 139–43 . March 2004 . 14722670 . 10.1007/s00262-003-0471-y . 10785466 . free . 11032928 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D . Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope . The American Journal of Pathology . 160 . 5 . 1669–81 . May 2002 . 12000719 . 1850881 . 10.1016/S0002-9440(10)61114-5 .
• Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC . Serological identification and expression analysis of gastric cancer-associated genes . British Journal of Cancer . 86 . 11 . 1824–30 . June 2002 . 12087473 . 2375403 . 10.1038/sj.bjc.6600321 .
• Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D . Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin . The Journal of Investigative Dermatology . 119 . 6 . 1388–93 . December 2002 . 12485444 . 10.1046/j.1523-1747.2002.19647.x . free .
• Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M . Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling . . 16 . 9 . 1265–74 . September 2004 . 15249540 . 10.1093/intimm/dxh128 . free .
• Reckzeh K. . Kizilkaya H. . Søgaard Helbo A. . Estruch Alrich M. . 2018 . Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin . Blood Advances. 2 . 13 . 1628–1632 . 10.1182/bloodadvances.2018015743. etal . 6039657 . 29986855.

Notes and References

1. Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M . Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity . FEBS Letters . 499 . 1–2 . 121–6 . June 2001 . 11418125 . 10.1016/S0014-5793(01)02520-0 . 23615506 . free .
2. Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M . Human endomucin is an endothelial marker . Biochemical and Biophysical Research Communications . 288 . 1 . 129–36 . October 2001 . 11594763 . 10.1006/bbrc.2001.5737 .
3. Web site: Entrez Gene: EMCN endomucin.
4. Liu C . etal . 2001 . Human Endomucin Is an Endothelial Marker . Biochemical and Biophysical Research Communications . 288 . 1 . 129–136 . 10.1006/bbrc.2001.5737 . 11594763.
5. Matsubara A.. 2005 . Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. . Journal of Experimental Medicine. 11 . 202 . 1483–1492 . 10.1084/jem.20051325. etal . 2213340 . 16314436.