ELOA explained

Elongin A is a protein that in humans is encoded by the ELOA gene.^{[1] [2] [3]}

Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C. The von Hippel–Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation.

Further reading

• Shilatifard A . Factors regulating the transcriptional elongation activity of RNA polymerase II . FASEB J. . 12 . 14 . 1437–46 . 1998 . 10.1096/fasebj.12.14.1437 . free . 9806752 . 17435359 .
• Kile BT, Schulman BA, Alexander WS, etal . The SOCS box: a tale of destruction and degradation . Trends Biochem. Sci. . 27 . 5 . 235–41 . 2002 . 12076535 . 10.1016/S0968-0004(02)02085-6 .
• Aso T, Haque D, Fukudome K, etal . A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin . Gene . 168 . 2 . 277–8 . 1996 . 8654961 . 10.1016/0378-1119(95)00750-4 .
• Pan G, Aso T, Greenblatt J . Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators . J. Biol. Chem. . 272 . 39 . 24563–71 . 1997 . 9305922 . 10.1074/jbc.272.39.24563 . free .
• Ohh M, Takagi Y, Aso T, etal . Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein . J. Clin. Invest. . 104 . 11 . 1583–91 . 2000 . 10587522 . 10.1172/JCI8161 . 481054 .
• Kamura T, Burian D, Yan Q, etal . Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase . J. Biol. Chem. . 276 . 32 . 29748–53 . 2001 . 11384984 . 10.1074/jbc.M103093200 . free.
• Shaheduzzaman S, Krishnan V, Petrovic A, etal . Effects of HIV-1 Nef on cellular gene expression profiles . J. Biomed. Sci. . 9 . 1 . 82–96 . 2002 . 11810028 . 10.1007/BF02256581 .
• Yamazaki K, Guo L, Sugahara K, etal . Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3 . J. Biol. Chem. . 277 . 29 . 26444–51 . 2002 . 11994304 . 10.1074/jbc.M202859200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tamura K, Miyata K, Sugahara K, etal . Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain . Biochem. Biophys. Res. Commun. . 309 . 1 . 189–95 . 2003 . 12943681 . 10.1016/S0006-291X(03)01556-0 .
• Stoletov KV, Terman BI . Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation . Biochem. Biophys. Res. Commun. . 320 . 1 . 70–5 . 2004 . 15207703 . 10.1016/j.bbrc.2004.05.134 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Woo JS, Imm JH, Min CK, etal . Structural and functional insights into the B30.2/SPRY domain . EMBO J. . 25 . 6 . 1353–63 . 2006 . 16498413 . 10.1038/sj.emboj.7600994 . 1422157 .

Notes and References

1. Aso T, Mokady N, Haque D, Conaway RC, Conaway JW . Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1 . Genomics . 30 . 2 . 393–4 . Mar 1996 . 8586449 .
2. Aso T, Lane WS, Conaway JW, Conaway RC . Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II . Science . 269 . 5229 . 1439–43 . Oct 1995 . 7660129 . 10.1126/science.7660129 . 1995Sci...269.1439A . 37649908 .
3. Web site: ELOA elongin A [Homo sapiens (human) ]].