ELL (gene) explained

RNA polymerase II elongation factor ELL is an enzyme that in humans is encoded by the ELL gene.^{[1] [2] [3]}

Interactions

ELL (gene) has been shown to interact with P53.^[4]

Further reading

• Iwabuchi K, Bartel PL, Li B, Marraccino R, Fields S . Two cellular proteins that bind to wild-type but not mutant p53. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 13 . 6098–102 . 1994 . 8016121 . 44145 . 10.1073/pnas.91.13.6098 . 1994PNAS...91.6098I . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Shilatifard A, Haque D, Conaway RC, Conaway JW . Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex . J. Biol. Chem. . 272 . 35 . 22355–63 . 1997 . 9268387 . 10.1074/jbc.272.35.22355 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Shilatifard A . Identification and purification of the Holo-ELL complex. Evidence for the presence of ELL-associated proteins that suppress the transcriptional inhibitory activity of ELL . J. Biol. Chem. . 273 . 18 . 11212–7 . 1998 . 9556611 . 10.1074/jbc.273.18.11212 . free .
• Li XY, Green MR . The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor . Genes Dev. . 12 . 19 . 2992–6 . 1998 . 9765201 . 317190 . 10.1101/gad.12.19.2992 .
• Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, Hatakeyama M . Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53 . J. Biol. Chem. . 274 . 24 . 17003–10 . 1999 . 10358050 . 10.1074/jbc.274.24.17003 . free .
• Schmidt AE, Miller T, Schmidt SL, Shiekhattar R, Shilatifard A . Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II . J. Biol. Chem. . 274 . 31 . 21981–5 . 1999 . 10419521 . 10.1074/jbc.274.31.21981 . free .
• Kim MK, Nikodem VM . hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation . Mol. Cell. Biol. . 19 . 10 . 6833–44 . 2000 . 10490622 . 84680 . 10.1128/MCB.19.10.6833.
• Lavau C, Luo RT, Du C, Thirman MJ . Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice . Proc. Natl. Acad. Sci. U.S.A. . 97 . 20 . 10984–9 . 2000 . 10995463 . 27135 . 10.1073/pnas.190167297 . 2000PNAS...9710984L . free .
• Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ . EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein . Blood . 98 . 1 . 201–9 . 2001 . 11418481 . 10.1182/blood.V98.1.201 . 2577367 .
• Luo RT, Lavau C, Du C, Simone F, Polak PE, Kawamata S, Thirman MJ . The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis . Mol. Cell. Biol. . 21 . 16 . 5678–87 . 2001 . 11463848 . 87288 . 10.1128/MCB.21.16.5678-5687.2001 .
• Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ . ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties . Blood . 101 . 6 . 2355–62 . 2003 . 12446457 . 10.1182/blood-2002-06-1664 . free .
• Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ . ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia . Mol. Biol. Cell . 14 . 4 . 1517–28 . 2003 . 12686606 . 153119 . 10.1091/mbc.E02-07-0394 .
• Wiederschain D, Kawai H, Gu J, Shilatifard A, Yuan ZM . Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL . Mol. Cell. Biol. . 23 . 12 . 4230–46 . 2003 . 12773566 . 156137 . 10.1128/MCB.23.12.4230-4246.2003 .

Notes and References

1. Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD . Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia . Proc Natl Acad Sci U S A . 91 . 25 . 12110–4 . Jan 1995 . 7991593 . 45386 . 10.1073/pnas.91.25.12110 . 1994PNAS...9112110T . free .
2. Shilatifard A, Lane WS, Jackson KW, Conaway RC, Conaway JW . An RNA polymerase II elongation factor encoded by the human ELL gene . Science . 271 . 5257 . 1873–6 . Apr 1996 . 8596958 . 10.1126/science.271.5257.1873 . 1996Sci...271.1873S . 46101044 .
3. Web site: Entrez Gene: ELL elongation factor RNA polymerase II.
4. Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, Hatakeyama M . Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53 . J. Biol. Chem. . 274 . 24 . 17003–10 . Jun 1999 . 10358050 . 10.1074/jbc.274.24.17003 . free .