ELF4 explained

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.^{[1] [2]}

Further reading

• Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD . The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2 . Molecular and Cellular Biology . 26 . 8 . 3114–23 . April 2006 . 16581786 . 1446966 . 10.1128/MCB.26.8.3114-3123.2006 .
• Moore SD, Offor O, Ferry JA, Amrein PC, Morton CC, Dal Cin P . ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22) . Leukemia Research . 30 . 8 . 1037–42 . August 2006 . 16303180 . 10.1016/j.leukres.2005.10.014 .
• Lu Z, Kim KA, Suico MA, Shuto T, Li JD, Kai H . MEF up-regulates human beta-defensin 2 expression in epithelial cells . FEBS Letters . 561 . 1–3 . 117–21 . March 2004 . 15013761 . 10.1016/S0014-5793(04)00138-3 . 86612269 . free . 2004FEBSL.561..117L .
• Suico MA, Yoshida H, Seki Y, Uchikawa T, Lu Z, Shuto T, Matsuzaki K, Nakao M, Li JD, Kai H . Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein . The Journal of Biological Chemistry . 279 . 18 . 19091–8 . April 2004 . 14976184 . 10.1074/jbc.M312439200 . free .
• Cho JY, Akbarali Y, Zerbini LF, Gu X, Boltax J, Wang Y, Oettgen P, Zhang DE, Libermann TA . Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene . The Journal of Biological Chemistry . 279 . 19 . 19512–22 . May 2004 . 14970218 . 10.1074/jbc.M309074200 . free .
• Hedvat CV, Yao J, Sokolic RA, Nimer SD . Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells . The Journal of Biological Chemistry . 279 . 8 . 6395–400 . February 2004 . 14625302 . 10.1074/jbc.M307524200 . free .
• Suico MA, Koyanagi T, Ise S, Lu Z, Hisatsune A, Seki Y, Shuto T, Isohama Y, Miyata T, Kai H . Functional dissection of the ETS transcription factor MEF . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1577 . 1 . 113–20 . August 2002 . 12151102 . 10.1016/s0167-4781(02)00370-6 .
• Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD . Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias . Molecular and Cellular Biology . 19 . 5 . 3635–44 . May 1999 . 10207087 . 84165 . 10.1128/mcb.19.5.3635 .
• Aryee DN, Petermann R, Kos K, Henn T, Haas OA, Kovar H . Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1 . Gene . 210 . 1 . 71–8 . March 1998 . 9524226 . 10.1016/S0378-1119(98)00022-5 .

Notes and References

1. Miyazaki Y, Sun X, Uchida H, Zhang J, Nimer S . MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties . Oncogene . 13 . 8 . 1721–9 . October 1996 . 8895518 .
2. Web site: Entrez Gene: ELF4 E74-like factor 4 (ets domain transcription factor).