ELF2 explained

E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor.^[1] In humans this protein is encoded by the ELF2 gene.^[2]

Further reading

• Wilkinson DA, Neale GA, Mao S . Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia. . Leukemia . 11 . 1 . 86–96 . 1997 . 9001422 . 10.1038/sj.leu.2400516 . etal. free .
• Mao S, Frank RC, Zhang J . Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. . Mol. Cell. Biol. . 19 . 5 . 3635–44 . 1999 . 10207087 . 10.1128/mcb.19.5.3635. 84165 . etal.
• Christensen RA, Fujikawa K, Madore R . NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia. . J. Cell. Biochem. . 85 . 3 . 505–15 . 2002 . 11967990 . 10.1002/jcb.10148 . 36902890 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Cho JY, Akbarali Y, Zerbini LF . Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. . J. Biol. Chem. . 279 . 19 . 19512–22 . 2004 . 14970218 . 10.1074/jbc.M309074200 . etal. free .
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Zhang B, Tomita Y, Qiu Y . E74-like factor 2 regulates valosin-containing protein expression. . Biochem. Biophys. Res. Commun. . 356 . 3 . 536–41 . 2007 . 17368566 . 10.1016/j.bbrc.2007.02.160 . etal.

Notes and References

1. Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA . Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1 . Mol. Cell. Biol. . 16 . 9 . 5091–106 . September 1996 . 8756667 . 231510 . 10.1128/MCB.16.9.5091.
2. Web site: Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor).