ELF1 explained

E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene.^[1]

Function

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and can act as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.^[1]

Further reading

• Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, Jiang X, Mager D, Humphries RK . Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1 . Experimental Hematology . 38 . 9 . 798–8, 808.e1-2 . Sep 2010 . 20600580 . 3887005 . 10.1016/j.exphem.2010.06.006 .
• Juang YT, Solomou EE, Rellahan B, Tsokos GC . Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain . Journal of Immunology . 168 . 6 . 2865–71 . Mar 2002 . 11884456 . 10.4049/jimmunol.168.6.2865 . free .
• Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD . Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias . Molecular and Cellular Biology . 19 . 5 . 3635–44 . May 1999 . 10207087 . 84165 . 10.1128/mcb.19.5.3635.
• Nishiyama C, Takahashi K, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T . Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1 . Bioscience, Biotechnology, and Biochemistry . 64 . 12 . 2601–7 . Dec 2000 . 11210123 . 10.1271/bbb.64.2601 . free .
• Thompson CB, Wang CY, Ho IC, Bohjanen PR, Petryniak B, June CH, Miesfeldt S, Zhang L, Nabel GJ, Karpinski B . cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1 . Molecular and Cellular Biology . 12 . 3 . 1043–53 . Mar 1992 . 1545787 . 369536 . 10.1128/mcb.12.3.1043.
• Tsokos GC, Nambiar MP, Juang YT . Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus . Annals of the New York Academy of Sciences . 987 . 240–5 . Apr 2003 . 12727645 . 10.1111/j.1749-6632.2003.tb06054.x . 42190457 .
• Gunther M, Laithier M, Brison O . A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening . Molecular and Cellular Biochemistry . 210 . 1–2 . 131–42 . Jul 2000 . 10976766 . 10.1023/A:1007177623283 . 1339642 .
• Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, Yang J, Cui Y, Zhang L, Hirankarn N, Cheng H, Pan HF, Gao J, Lee TL, Sheng Y, Lau CS, Li Y, Chan TM, Yin X, Ying D, Lu Q, Leung AM, Zuo X, Chen X, Tong KL, Zhou F, Diao Q, Tse NK, Xie H, Mok CC, Hao F, Wong SN, Shi B, Lee KW, Hui Y, Ho MH, Liang B, Lee PP, Cui H, Guo Q, Chung BH, Pu X, Liu Q, Zhang X, Zhang C, Chong CY, Fang H, Wong RW, Sun Y, Mok MY, Li XP, Avihingsanon Y, Zhai Z, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Gao F, Shotelersuk V, Kang X, Ying SK, Zhang L, Wong WH, Zhu D, Fung SK, Zeng F, Lai WM, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Shen N, Tam PK, Sham PC, Ye DQ, Yang S, Zhang X, Lau YL . 6 . Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians . American Journal of Human Genetics . 92 . 1 . 41–51 . Jan 2013 . 23273568 . 3542470 . 10.1016/j.ajhg.2012.11.018 .
• Bassuk AG, Anandappa RT, Leiden JM . Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells . Journal of Virology . 71 . 5 . 3563–73 . May 1997 . 10.1128/JVI.71.5.3563-3573.1997 . 9094628 . 191503 .

Notes and References

1. Web site: Entrez Gene: E74-like factor 1 (ets domain transcription factor) .