EIF5A2 explained

Eukaryotic translation initiation factor 5A-2 is a protein that in humans is encoded by the EIF5A2 gene.^[1]

Further reading

• Jenkins ZA, Hååg PG, Johansson HE . Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression. . . 71 . 1 . 101–9 . 2001 . 11161802 . 10.1006/geno.2000.6418 .
• Guan XY, Sham JS, Tang TC . Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer. . . 61 . 9 . 3806–9 . 2001 . 11325856 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Clement PM, Henderson CA, Jenkins ZA, Smit-McBride Z, Wolff EC, Hershey JW, Park MH, Johansson HE . Identification and characterization of eukaryotic initiation factor 5A-2. . . 270 . 21 . 4254–63 . 2003 . 14622290 . 10.1046/j.1432-1033.2003.03806.x . free .
• Guan XY, Fung JM, Ma NF . Oncogenic role of eIF-5A2 in the development of ovarian cancer. . Cancer Res. . 64 . 12 . 4197–200 . 2004 . 15205331 . 10.1158/0008-5472.CAN-03-3747 . 6823741 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Christensen GL, Ivanov IP, Atkins JF . Screening the SPO11 and EIF5A2 genes in a population of infertile men. . . 84 . 3 . 758–60 . 2005 . 16169419 . 10.1016/j.fertnstert.2005.03.053 . etal. free .
• Clement PM, Johansson HE, Wolff EC, Park MH . Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. . . 273 . 6 . 1102–14 . 2006 . 16519677 . 10.1111/j.1742-4658.2006.05135.x . 4406228 .
• Xie D, Ma NF, Pan ZZ, Wu HX, Liu YD, Wu GQ, Kung HF, Guan XY . Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. . . 39 . 1 . 80–6. 2008 . 17949776 . 10.1016/j.humpath.2007.05.011 .
• Yang GF, Xie D, Liu JH, Luo JH, Li LJ, Hua WF, Wu HM, Kung HF, Zeng YX, Guan XY . Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma. . Gynecol. Oncol. . 112 . 2 . 314–8 . 2009 . 19054548 . 10.1016/j.ygyno.2008.10.024 .
• Chen W, Luo JH, Hua WF, Zhou FJ, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D . Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. . . 18. 2 . 400–8 . 2009 . 19155439 . 10.1158/1055-9965.EPI-08-0754 . 9907553 .
• Luo JH, Hua WF, Rao HL, Liao YJ, Kung HF, Zeng YX, Guan XY, Chen W, Xie D . Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder. . . 100 . 5 . 896–902 . 2009 . 19298601 . 10.1111/j.1349-7006.2009.01126.x . 23225065 . 11158472 .
• Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY . Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. . . 51 . 4 . 1255–63 . 2010 . 20112425 . 10.1002/hep.23451 . 5328378 . free .
• Chen M, Huang JD, Deng HK, Dong S, Deng W, Tsang SL, Huen MS, Chen L, Zan T, Zhu GX, Guan XY . Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. . . 11 . 199 . 2011 . 21612665 . 10.1186/1471-2407-11-199 . 3118894 . free .
• He LR, Zhao HY, Li BK, Liu YH, Liu MZ, Guan XY, Bian XW, Zeng YX, Xie D . Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients. . . 129 . 1 . 143–50 . 2011 . 20830705 . 10.1002/ijc.25669 . 205942112 . free .

Notes and References

1. Web site: Entrez Gene: EIF5A2 eukaryotic translation initiation factor 5A2.