EIF5 explained

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.^{[1] [2]}

EIF5 is a GTPase-activating protein.^[3]

External links

• Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)

Further reading

• Das S, Maiti T, Das K, Maitra U . Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2. . J. Biol. Chem. . 272 . 50 . 31712–8 . 1998 . 9395514 . 10.1074/jbc.272.50.31712 . free .
• Bandyopadhyay A, Maitra U . Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells. . Nucleic Acids Res. . 27 . 5 . 1331–7 . 1999 . 9973622 . 10.1093/nar/27.5.1331 . 148320 .
• Das S, Maitra U . Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo. . Mol. Cell. Biol. . 20 . 11 . 3942–50 . 2000 . 10805737 . 10.1128/MCB.20.11.3942-3950.2000 . 85746 .
• Choi SK, Olsen DS, Roll-Mecak A . Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2. . Mol. Cell. Biol. . 20 . 19 . 7183–91 . 2000 . 10982835 . 10.1128/MCB.20.19.7183-7191.2000 . 86272 . etal.
• Das S, Ghosh R, Maitra U . Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein. . J. Biol. Chem. . 276 . 9 . 6720–6 . 2001 . 11092890 . 10.1074/jbc.M008863200 . free .
• Wiemann S, Weil B, Wellenreuther R . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Asano K, Shalev A, Phan L . Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation. . EMBO J. . 20 . 9 . 2326–37 . 2001 . 11331597 . 10.1093/emboj/20.9.2326 . 125443 . etal.
• Majumdar R, Bandyopadhyay A, Deng H, Maitra U . Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo. . Nucleic Acids Res. . 30 . 5 . 1154–62 . 2002 . 11861906 . 10.1093/nar/30.5.1154 . 101238 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Marintchev A, Kolupaeva VG, Pestova TV, Wagner G . Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 4 . 1535–40 . 2003 . 12569173 . 10.1073/pnas.0437845100 . 149867 . 2003PNAS..100.1535M . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Homma MK, Wada I, Suzuki T . CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression. . Proc. Natl. Acad. Sci. U.S.A. . 102 . 43 . 15688–93 . 2005 . 16227438 . 10.1073/pnas.0506791102 . 1266118 . 2005PNAS..10215688H . etal. free .
• Conte MR, Kelly G, Babon J . Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. . Biochemistry . 45 . 14 . 4550–8 . 2006 . 16584190 . 10.1021/bi052387u . etal.
• Bieniossek C, Schütz P, Bumann M . The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5. . J. Mol. Biol. . 360 . 2 . 457–65 . 2006 . 16781736 . 10.1016/j.jmb.2006.05.021 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . etal. free .

Notes and References

1. Si K, Das K, Maitra U . Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5) . J Biol Chem . 271 . 28 . 16934–8 . Aug 1996 . 8663286 . 10.1074/jbc.271.28.16934 . free.
2. Web site: Entrez Gene: EIF5 eukaryotic translation initiation factor 5.
3. Das S, Ghosh R, Maitra U . Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein . J. Biol. Chem. . 276 . 9 . 6720–6 . March 2001 . 11092890 . 10.1074/jbc.M008863200 . free .