EIF4ENIF1 explained

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.^{[1] [2]}

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.^[3]

Interactions

EIF4ENIF1 has been shown to interact with EIF4E.

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Warner DR, Roberts EA, Greene RM, Pisano MM . Identification of novel Smad binding proteins. . Biochem. Biophys. Res. Commun. . 312 . 4 . 1185–90 . 2004 . 14651998 . 10.1016/j.bbrc.2003.11.049 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Ballif BA, Villén J, Beausoleil SA . Phosphoproteomic analysis of the developing mouse brain. . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . etal. free .
• Collins JE, Wright CL, Edwards CA . A genome annotation-driven approach to cloning the human ORFeome. . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . etal . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Andrei MA, Ingelfinger D, Heintzmann R . A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. . RNA . 11 . 5 . 717–27 . 2005 . 15840819 . 10.1261/rna.2340405 . 1370757 . etal.
• Ferraiuolo MA, Basak S, Dostie J . A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. . J. Cell Biol. . 170 . 6 . 913–24 . 2005 . 16157702 . 10.1083/jcb.200504039 . 2171455 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Wichroski MJ, Robb GB, Rana TM . Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. . PLOS Pathog. . 2 . 5 . e41 . 2006 . 16699599 . 10.1371/journal.ppat.0020041 . 1458959 . free .
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . etal. free .
• Denoeud F, Kapranov P, Ucla C . Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. . Genome Res. . 17 . 6 . 746–59 . 2007 . 17567994 . 10.1101/gr.5660607 . 1891335 . etal.

Notes and References

1. Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N . A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E . EMBO J . 19 . 12 . 3142–56 . Aug 2000 . 10856257 . 203362 . 10.1093/emboj/19.12.3142 .
2. Web site: Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1.
3. Web site: Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1.