EIF4EBP3 explained
Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.[1] [2]
Function
This gene encodes a member of the EIF4EBP family which derives its name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.[2]
Interactions
EIF4EBP3 has been shown to interact with EIF4E.[3]
Further reading
- Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Joshi B, Cameron A, Jagus R . Characterization of mammalian eIF4E-family members . Eur. J. Biochem. . 271 . 11 . 2189–203 . 2004 . 15153109 . 10.1111/j.1432-1033.2004.04149.x . free .
- Poulin F, Brueschke A, Sonenberg N . Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK . J. Biol. Chem. . 278 . 52 . 52290–7 . 2003 . 14557257 . 10.1074/jbc.M310761200 . free .
- Ferguson G, Mothe-Satney I, Lawrence JC . Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E . J. Biol. Chem. . 278 . 48 . 47459–65 . 2003 . 14507920 . 10.1074/jbc.M307949200 . free .
- Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG . Localisation and regulation of the eIF4E-binding protein 4E-BP3 . FEBS Lett. . 532 . 3 . 319–23 . 2002 . 12482586 . 10.1016/S0014-5793(02)03694-3 . 24527449 .
Notes and References
- Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N . 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family . J. Biol. Chem. . 273 . 22 . 14002–7 . Jul 1998 . 9593750 . 10.1074/jbc.273.22.14002 . free .
- Web site: Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3.
- Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG . Localisation and regulation of the eIF4E-binding protein 4E-BP3 . FEBS Lett. . 532 . 3 . 319–23 . Dec 2002 . 12482586 . 10.1016/S0014-5793(02)03694-3 . 24527449 .
