EIF4E2 explained

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.^{[1] [2] [3] [4]} It belongs to the eukaryotic translation initiation factor 4E family.

Interactions

EIF4E2 has been shown to interact with ARIH1.^[5]

Further reading

• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . 6 . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–1560 . October 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA . Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP . FEBS Letters . 554 . 3 . 501–504 . November 2003 . 14623119 . 10.1016/S0014-5793(03)01235-3 . 25441190 .
• Tee AR, Tee JA, Blenis J . Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1 . FEBS Letters . 564 . 1–2 . 58–62 . April 2004 . 15094042 . 10.1016/S0014-5793(04)00313-8 . 32997726 .
• Joshi B, Cameron A, Jagus R . Characterization of mammalian eIF4E-family members . European Journal of Biochemistry . 271 . 11 . 2189–2203 . June 2004 . 15153109 . 10.1111/j.1432-1033.2004.04149.x . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . Huda Zoghbi .
• Okumura F, Zou W, Zhang DE . ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP . Genes & Development . 21 . 3 . 255–260 . February 2007 . 17289916 . 1785121 . 10.1101/gad.1521607 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 6 . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD . Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms . Journal of Molecular Biology . 368 . 3 . 691–705 . May 2007 . 17368478 . 10.1016/j.jmb.2007.02.019 .
• Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, Darzynkiewicz E . Weak binding affinity of human 4EHP for mRNA cap analogs . RNA . 13 . 5 . 691–697 . May 2007 . 17369309 . 1852817 . 10.1261/rna.453107 .

Notes and References

1. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z . 6 . Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proceedings of the National Academy of Sciences of the United States of America . 95 . 14 . 8175–8180 . July 1998 . 9653160 . 20949 . 10.1073/pnas.95.14.8175 . 1998PNAS...95.8175M . free .
2. Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK, Sonenberg N . 6 . Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein . The Journal of Biological Chemistry . 273 . 21 . 13104–13109 . May 1998 . 9582349 . 10.1074/jbc.273.21.13104 . free .
3. Web site: Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2.
4. Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N . 6 . A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development . Molecular and Cellular Biology . 32 . 17 . 3585–3593 . September 2012 . 22751931 . 3422012 . 10.1128/MCB.00455-12 .
5. Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA . Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP . FEBS Letters . 554 . 3 . 501–504 . November 2003 . 14623119 . 10.1016/S0014-5793(03)01235-3 . 25441190 .