EIF3S6 explained

Eukaryotic translation initiation factor 3 subunit E (eIF3e) is a protein that in humans is encoded by the EIF3E gene.^{[1] [2] [3]}

Interactions

EIF3S6 has been shown to interact with:

• BAT2,^[4]
• COPS6^[5]
• CSN3,^[5]
• EIF3A,^{[6] [7] [8]} and
• TRIM27.^[9]

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

• Marchetti A, Buttitta F, Miyazaki S, Gallahan D, Smith GH, Callahan R . Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia . J. Virol. . 69 . 3 . 1932–8 . 1995 . 10.1128/JVI.69.3.1932-1938.1995 . 7853537 . 188811 .
• Desbois C, Rousset R, Bantignies F, Jalinot P . Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein . Science . 273 . 5277 . 951–3 . 1996 . 8688078 . 10.1126/science.273.5277.951 . 1996Sci...273..951D . 975513 .
• Asano K, Kinzy TG, Merrick WC, Hershey JW . Conservation and diversity of eukaryotic translation initiation factor eIF3 . J. Biol. Chem. . 272 . 2 . 1101–9 . 1997 . 8995409 . 10.1074/jbc.272.2.1101 . free .
• Méthot N, Rom E, Olsen H, Sonenberg N . The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 . J. Biol. Chem. . 272 . 2 . 1110–6 . 1997 . 8995410 . 10.1074/jbc.272.2.1110 . free .
• Block KL, Vornlocher HP, Hershey JW . Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 . J. Biol. Chem. . 273 . 48 . 31901–8 . 1998 . 9822659 . 10.1074/jbc.273.48.31901 . free .
• Guo J, Sen GC . Characterization of the interaction between the interferon-induced protein P56 and the Int6 protein encoded by a locus of insertion of the mouse mammary tumor virus . J. Virol. . 74 . 4 . 1892–9 . 2000 . 10644362 . 111667 . 10.1128/JVI.74.4.1892-1899.2000 .
• Guo J, Hui DJ, Merrick WC, Sen GC . A new pathway of translational regulation mediated by eukaryotic initiation factor 3 . EMBO J. . 19 . 24 . 6891–9 . 2000 . 11118224 . 305884 . 10.1093/emboj/19.24.6891 .
• Yen HC, Chang EC . Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation . Proc. Natl. Acad. Sci. U.S.A. . 97 . 26 . 14370–5 . 2000 . 11121040 . 18925 . 10.1073/pnas.97.26.14370 . 2000PNAS...9714370Y . free .
• Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P . The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3 . J. Biol. Chem. . 276 . 49 . 45988–95 . 2001 . 11590142 . 10.1074/jbc.M104966200 . free .
• Neuveut C, Jin DY, Semmes OJ, Diella F, Callahan R, Jeang KT . Divergent Subcellular Locations of HTLV-I Tax and Int-6: A Contrast between in vitro Protein-Protein Binding and Intracellular Protein Colocalization . J. Biomed. Sci. . 4 . 5 . 229–234 . 1997 . 12386384 . 10.1007/BF02253422 .
• Huang GJ, Zhang ZQ, Jin DY . Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax . FEBS Lett. . 531 . 3 . 494–8 . 2002 . 12435599 . 10.1016/S0014-5793(02)03590-1 . 86061142 .
• Yen HC, Gordon C, Chang EC . Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome . Cell . 112 . 2 . 207–17 . 2003 . 12553909 . 10.1016/S0092-8674(03)00043-6 . 17124800 . free .
• Watkins SJ, Norbury CJ . Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts . Cell Prolif. . 37 . 2 . 149–60 . 2004 . 15030549 . 10.1111/j.1365-2184.2004.00305.x . 6495725 .

Notes and References

1. Miyazaki S, Imatani A, Ballard L, Marchetti A, Buttitta F, Albertsen H, Nevanlinna HA, Gallahan D, Callahan R . The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas . Genomics . 46 . 1 . 155–8 . 1997 . 9403073 . 10.1006/geno.1997.4996 .
2. Asano K, Merrick WC, Hershey JW . The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome . J. Biol. Chem. . 272 . 38 . 23477–80 . October 1997 . 9295280 . 10.1074/jbc.272.38.23477 . free .
3. Web site: Entrez Gene: EIF3S6 Eukaryotic translation initiation factor 3, subunit 6 48kDa.
4. Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . January 2004 . 14667819 . 10.1016/s0888-7543(03)00235-0.
5. Hoareau Alves K, Bochard V, Réty S, Jalinot P . Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome . FEBS Lett. . 527 . 1–3 . 15–21 . September 2002 . 12220626 . 10.1016/s0014-5793(02)03147-2. 39308598 . free .
6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
7. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . Eur. J. Biochem. . 270 . 20 . 4133–9 . October 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x. free .
8. Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P . The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3 . J. Biol. Chem. . 276 . 49 . 45988–95 . December 2001 . 11590142 . 10.1074/jbc.M104966200 . free .
9. Morris-Desbois C, Bochard V, Reynaud C, Jalinot P . Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies . J. Cell Sci. . 112 (Pt 19) . 3331–42 . October 1999 . 19 . 10.1242/jcs.112.19.3331 . 10504338 .