EIF3H explained

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.^{[1] [2]}

Interactions

eIF3h has been shown to interact with eIF3a.^{[3] [4] [5]}

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Asano K, Kinzy TG, Merrick WC, Hershey JW . Conservation and diversity of eukaryotic translation initiation factor eIF3 . J. Biol. Chem. . 272 . 2 . 1101–9 . 1997 . 8995409 . 10.1074/jbc.272.2.1101 . free .
• Méthot N, Rom E, Olsen H, Sonenberg N . The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 . J. Biol. Chem. . 272 . 2 . 1110–6 . 1997 . 8995410 . 10.1074/jbc.272.2.1110 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Block KL, Vornlocher HP, Hershey JW . Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 . J. Biol. Chem. . 273 . 48 . 31901–8 . 1998 . 9822659 . 10.1074/jbc.273.48.31901 . free .
• Saramäki O, Willi N, Bratt O, Gasser TC, Koivisto P, Nupponen NN, Bubendorf L, Visakorpi T . Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer . Am. J. Pathol. . 159 . 6 . 2089–94 . 2001 . 11733359 . 1850612 . 10.1016/S0002-9440(10)63060-X .
• Morris JA, Kandpal G, Ma L, Austin CP . DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation . Hum. Mol. Genet. . 12 . 13 . 1591–608 . 2003 . 12812986 . 10.1093/hmg/ddg162 . free .
• Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . Eur. J. Biochem. . 270 . 20 . 4133–9 . 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x . free .
• Okamoto H, Yasui K, Zhao C, Arii S, Inazawa J . PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas . Hepatology . 38 . 5 . 1242–9 . 2003 . 14578863 . 10.1053/jhep.2003.50457 . 21888517 . free .
• Savinainen KJ, Linja MJ, Saramäki OR, Tammela TL, Chang GT, Brinkmann AO, Visakorpi T . Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer . Br. J. Cancer . 90 . 5 . 1041–6 . 2004 . 14997205 . 2409619 . 10.1038/sj.bjc.6601648 .
• Savinainen KJ, Helenius MA, Lehtonen HJ, Visakorpi T . Overexpression of EIF3S3 promotes cancer cell growth . Prostate . 66 . 11 . 1144–50 . 2006 . 16652384 . 10.1002/pros.20452 . 2281409 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW . Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly . J. Biol. Chem. . 272 . 43 . 27042–52 . Nov 1997 . 9341143 . 10.1074/jbc.272.43.27042 . free .
2. Web site: Entrez Gene: EIF3S3 eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa.
3. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
4. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . Eur. J. Biochem. . 270 . 20 . 4133–9 . Oct 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x . free .
5. Block KL, Vornlocher HP, Hershey JW . Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 . J. Biol. Chem. . 273 . 48 . 31901–8 . Nov 1998 . 9822659 . 10.1074/jbc.273.48.31901 . free .