EIF3A explained

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene.^{[1] [2] [3]} It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

Interactions

EIF3A has been shown to interact with:

• DISC1,^[4]
• EIF3B,^{[5] [6]}
• EIF3C,
• EIF3D,^{[7] [8]}
• EIF3EIP,^{[9] [10]}
• EIF3F,^{[7] [8] [9]}
• EIF3G,^{[7] [8]}
• EIF3H,^{[7] [8] [9]}
• EIF3I^{[7] [9] [11]}
• EIF3J,^{[7] [8]}
• EIF3K,^{[7] [9]}
• EIF3S6,^{[7] [9] [10]}
• EIF4B,^[12]
• EIF4G2,^{[13] [14]} and
• FBXO32.^[15]

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

• Dong Z, Zhang JT . Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer . Crit. Rev. Oncol. Hematol. . 59 . 3 . 169–80 . 2006 . 16829125 . 10.1016/j.critrevonc.2006.03.005 .
• Kanner SB, Reynolds AB, Vines RR, Parsons JT . Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases . Proc. Natl. Acad. Sci. U.S.A. . 87 . 9 . 3328–32 . 1990 . 2110361 . 53893 . 10.1073/pnas.87.9.3328 . free . 1990PNAS...87.3328K .
• Scholler JK, Kanner SB . The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex . DNA Cell Biol. . 16 . 4 . 515–31 . 1997 . 9150439 . 10.1089/dna.1997.16.515 .
• Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D . The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities . Cell . 95 . 2 . 279–89 . 1998 . 9790534 . 10.1016/S0092-8674(00)81758-4 . 18786866 . free .
• Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL . Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex . Nature . 395 . 6705 . 917–21 . 1998 . 9804427 . 10.1038/27699 . 1998Natur.395..917T . 4355885 .
• Block KL, Vornlocher HP, Hershey JW . Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 . J. Biol. Chem. . 273 . 48 . 31901–8 . 1998 . 9822659 . 10.1074/jbc.273.48.31901 . free .
• Ensinger C, Obrist P, Mikuz G, Merkx G, Smeets D, Bänziger R, Bachmann F, Burger M . Assignment1 of the p150 subunit of the eukaryotic initiation factor 3A gene (EIF3A) to human chromosome band 10q26 by in situ hybridisation . Cytogenet. Cell Genet. . 83 . 1–2 . 74–5 . 1998 . 9925932 . 10.1159/000015130 . 2664052 .
• Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D . Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation . Genes Dev. . 13 . 15 . 1924–35 . 1999 . 10444591 . 316920 . 10.1101/gad.13.15.1924 .
• Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH . Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 . J. Biol. Chem. . 276 . 9 . 6817–24 . 2001 . 11102443 . 10.1074/jbc.M007372200 . free .
• Lin L, Holbro T, Alonso G, Gerosa D, Burger MM . Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7 . J. Cell. Biochem. . 80 . 4 . 483–90 . 2001 . 11169732 . 10.1002/1097-4644(20010315)80:4<483::AID-JCB1002>3.0.CO;2-B . 35848129 .
• Pincheira R, Chen Q, Zhang JT . Identification of a 170-kDa protein over-expressed in lung cancers . Br. J. Cancer . 84 . 11 . 1520–7 . 2001 . 11384103 . 2363652 . 10.1054/bjoc.2001.1828 .
• Saito M, Ishikawa F . The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2 . J. Biol. Chem. . 277 . 38 . 35434–9 . 2002 . 12124384 . 10.1074/jbc.M203455200 . free .

Notes and References

1. Johnson KR, Merrick WC, Zoll WL, Zhu Y . Identification of cDNA clones for the large subunit of eukaryotic translation initiation factor 3. Comparison of homologues from human, Nicotiana tabacum, Caenorhabditis elegans, and Saccharomyces cerevisiae . J. Biol. Chem. . 272 . 11 . 7106–13 . April 1997 . 9054404 . 10.1074/jbc.272.11.7106 . free .
2. Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N . Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 2 . 4 . 167–74, 199–210 . 1995 . 8590280 . 10.1093/dnares/2.4.167 .
3. Web site: Entrez Gene: EIF3S10 eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa.
4. Morris JA, Kandpal G, Ma L, Austin CP . DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation . Hum. Mol. Genet. . 12 . 13 . 1591–608 . July 2003 . 12812986 . 10.1093/hmg/ddg162.
5. Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC . mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin . EMBO J. . 25 . 8 . 1659–68 . April 2006 . 16541103 . 1440840 . 10.1038/sj.emboj.7601047 .
6. Méthot N, Rom E, Olsen H, Sonenberg N . The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 . J. Biol. Chem. . 272 . 2 . 1110–6 . January 1997 . 8995410 . 10.1074/jbc.272.2.1110. free .
7. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . Eur. J. Biochem. . 270 . 20 . 4133–9 . October 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x. free .
8. Block KL, Vornlocher HP, Hershey JW . Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 . J. Biol. Chem. . 273 . 48 . 31901–8 . November 1998 . 9822659 . 10.1074/jbc.273.48.31901. free .
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
10. Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P . The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3 . J. Biol. Chem. . 276 . 49 . 45988–95 . December 2001 . 11590142 . 10.1074/jbc.M104966200 . free .
11. Asano K, Kinzy TG, Merrick WC, Hershey JW . Conservation and diversity of eukaryotic translation initiation factor eIF3 . J. Biol. Chem. . 272 . 2 . 1101–9 . January 1997 . 8995409 . 10.1074/jbc.272.2.1101. free .
12. Méthot N, Song MS, Sonenberg N . A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3 . Mol. Cell. Biol. . 16 . 10 . 5328–34 . October 1996 . 8816444 . 231531 . 10.1128/MCB.16.10.5328.
13. Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N . A novel functional human eukaryotic translation initiation factor 4G . Mol. Cell. Biol. . 18 . 1 . 334–42 . January 1998 . 9418880 . 121501 . 10.1128/mcb.18.1.334.
14. Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A . A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation . Mol. Cell. Biol. . 20 . 2 . 496–506 . January 2000 . 10611228 . 85113 . 10.1128/mcb.20.2.496-506.2000.
15. Lagirand-Cantaloube J, Offner N, Csibi A, Leibovitch MP, Batonnet-Pichon S, Tintignac LA, Segura CT, Leibovitch SA . The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy . EMBO J. . 27 . 8 . 1266–76 . April 2008 . 18354498 . 2367397 . 10.1038/emboj.2008.52 .