EIF2S3 explained

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.^{[1] [2] [3]}

Function

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β), and gamma (γ, this article), with the protein encoded by this gene representing the gamma subunit.^[3]

See also

• eIF2

Further reading

• Ray MK, Chakraborty A, Datta B . Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide . Biochemistry . 32 . 19 . 5151–9 . 1993 . 8098621 . 10.1021/bi00070a026 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Brand SR, Kobayashi R, Mathews MB . The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR . J. Biol. Chem. . 272 . 13 . 8388–95 . 1997 . 9079663 . 10.1074/jbc.272.13.8388 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Cai R, Carpick B, Chun RF . HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms . Arch. Biochem. Biophys. . 373 . 2 . 361–7 . 2000 . 10620360 . 10.1006/abbi.1999.1583 . etal.
• Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R . Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2 . Nucleic Acids Res. . 28 . 4 . 1011–8 . 2000 . 10648795 . 10.1093/nar/28.4.1011 . 102579 .
• Kruger M, Beger C, Li QX . Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach . Proc. Natl. Acad. Sci. U.S.A. . 97 . 15 . 8566–71 . 2000 . 10900014 . 10.1073/pnas.97.15.8566 . 26988 . 2000PNAS...97.8566K . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Andersen JS, Lam YW, Leung AK . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 . etal.
• Filippova GN, Cheng MK, Moore JM . Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development . Dev. Cell . 8 . 1 . 31–42 . 2005 . 15669143 . 10.1016/j.devcel.2004.10.018 . etal. free .
• Marques AC, Dupanloup I, Vinckenbosch N . Emergence of young human genes after a burst of retroposition in primates . PLOS Biol. . 3 . 11 . e357 . 2006 . 16201836 . 10.1371/journal.pbio.0030357 . 1251493 . etal . free .
• Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV . Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases . Biochem. Biophys. Res. Commun. . 338 . 4 . 1766–72 . 2006 . 16288713 . 10.1016/j.bbrc.2005.10.150 .
• Mikami S, Masutani M, Sonenberg N . An efficient mammalian cell-free translation system supplemented with translation factors . Protein Expr. Purif. . 46 . 2 . 348–57 . 2006 . 16289705 . 10.1016/j.pep.2005.09.021 . etal.
• Tu LC, Yan X, Hood L, Lin B . Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells . Mol. Cell. Proteomics . 6 . 4 . 575–88 . 2007 . 17220478 . 10.1074/mcp.M600249-MCP200 . free.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC . Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit . J Biol Chem . 269 . 5 . 3415–22 . Mar 1994 . 10.1016/S0021-9258(17)41878-3 . 8106381 . free .
2. Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM . Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution . Hum Mol Genet . 7 . 11 . 1725–37 . Dec 1998 . 9736774 . 10.1093/hmg/7.11.1725 . free .
3. Web site: Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa.