LGTN explained

Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene.^{[1] [2]} This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

Function

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.

See also

• Eukaryotic translation
• Eukaryotic initiation factor

Further reading

• Jakoi ER, Ross PE, Ping Ting-Beall H, Kaufman B, Vanaman TC . Ligatin: a peripheral membrane protein with covalently bound palmitic acid . The Journal of Biological Chemistry . 262 . 3 . 1300–4 . January 1987 . 10.1016/S0021-9258(19)75786-X . 3805022 . free .
• Gaston SM, Marchase RB, Jakoi ER . Brain ligatin: a membrane lectin that binds acetylcholinesterase . Journal of Cellular Biochemistry . 18 . 4 . 447–59 . 1982 . 7085778 . 10.1002/jcb.1982.240180406 . 22975039 .
• Marchase RB, Koro LA, Kelly CM, McClay DR . A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion . Journal of Cellular Biochemistry . 18 . 4 . 461–8 . 1982 . 7085779 . 10.1002/jcb.1982.240180407 . 44992995 .
• Jakoi ER, Kempe K, Gaston SM . Ligatin binds phosphohexose residues on acidic hydrolases . Journal of Supramolecular Structure and Cellular Biochemistry . 16 . 2 . 139–53 . 1982 . 7299841 . 10.1002/jsscb.1981.380160205 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF . Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies . Journal of Immunology . 169 . 2 . 1102–9 . July 2002 . 12097419 . 10.4049/jimmunol.169.2.1102 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Jakoi ER, Brown AL, Ho YS, Snyderman R . Molecular cloning of the cDNA for ligatin . Journal of Cell Science . 93 (Pt 2) . 2 . 227–32 . June 1989 . 10.1242/jcs.93.2.227 . 2482295 .
2. Web site: Entrez Gene: LGTN ligatin.