EIF2B5 explained

Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the EIF2B5 gene.^{[1] [2]}

Interactions

EIF2B5 has been shown to interact with EIF2B2^[3] and EIF2B1.^{[3] [4]}

Further reading

• Leegwater PA, Pronk JC, van der Knaap MS . Leukoencephalopathy with vanishing white matter: from magnetic resonance imaging pattern to five genes . Journal of Child Neurology . 18 . 9 . 639–45 . Sep 2003 . 14572143 . 10.1177/08830738030180091101 . 22639954 .
• Chaudhri MA, Crawford AC . Carbon determination in human teeth by activation with He-3 ions . Biological Trace Element Research . 26-27 . 521–7 . 1991 . 1704758 . 10.1007/BF02992708 . 32236889 .
• Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG . T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3 . The Journal of Biological Chemistry . 271 . 19 . 11410–3 . May 1996 . 8626696 . 10.1074/jbc.271.19.11410 . free .
• Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS . Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B . The Journal of Biological Chemistry . 273 . 5 . 3039–44 . Jan 1998 . 9446619 . 10.1074/jbc.273.5.3039 . free .
• Welsh GI, Miller CM, Loughlin AJ, Price NT, Proud CG . Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin . FEBS Letters . 421 . 2 . 125–30 . Jan 1998 . 9468292 . 10.1016/S0014-5793(97)01548-2 . 29189093 .
• Leegwater PA, Könst AA, Kuyt B, Sandkuijl LA, Naidu S, Oudejans CB, Schutgens RB, Pronk JC, van der Knaap MS . The gene for leukoencephalopathy with vanishing white matter is located on chromosome 3q27 . American Journal of Human Genetics . 65 . 3 . 728–34 . Sep 1999 . 10441579 . 1377979 . 10.1086/302548 .
• Gomez E, Pavitt GD . Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation . Molecular and Cellular Biology . 20 . 11 . 3965–76 . Jun 2000 . 10805739 . 85753 . 10.1128/MCB.20.11.3965-3976.2000 .
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS . Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation . Biochimica et Biophysica Acta . 1492 . 1 . 56–62 . Jun 2000 . 10858531 . 10.1016/S0167-4781(00)00062-2 .
• Williams DD, Price NT, Loughlin AJ, Proud CG . Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein . The Journal of Biological Chemistry . 276 . 27 . 24697–703 . Jul 2001 . 11323413 . 10.1074/jbc.M011788200 . free .
• Wang X, Paulin FE, Campbell LE, Gomez E, O'Brien K, Morrice N, Proud CG . Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo . The EMBO Journal . 20 . 16 . 4349–59 . Aug 2001 . 11500362 . 125262 . 10.1093/emboj/20.16.4349 .
• Leegwater PA, Vermeulen G, Könst AA, Naidu S, Mulders J, Visser A, Kersbergen P, Mobach D, Fonds D, van Berkel CG, Lemmers RJ, Frants RR, Oudejans CB, Schutgens RB, Pronk JC, van der Knaap MS . Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter . Nature Genetics . 29 . 4 . 383–8 . Dec 2001 . 11704758 . 10.1038/ng764 . 20313523 .
• Wang X, Janmaat M, Beugnet A, Paulin FE, Proud CG . Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin . The Biochemical Journal . 367 . Pt 2 . 475–81 . Oct 2002 . 12133000 . 1222905 . 10.1042/BJ20020677 .
• Fogli A, Wong K, Eymard-Pierre E, Wenger J, Bouffard JP, Goldin E, Black DN, Boespflug-Tanguy O, Schiffmann R . Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus . Annals of Neurology . 52 . 4 . 506–10 . Oct 2002 . 12325082 . 10.1002/ana.10339 . 35748869 . free .
• Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E . A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation . Neurology . 59 . 12 . 1966–8 . Dec 2002 . 12499492 . 10.1212/01.wnl.0000041666.76863.47 . 13129517 .
• Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O . Ovarian failure related to eukaryotic initiation factor 2B mutations . American Journal of Human Genetics . 72 . 6 . 1544–50 . Jun 2003 . 12707859 . 1180314 . 10.1086/375404 .
• van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC . eIF2B-related disorders: antenatal onset and involvement of multiple organs . American Journal of Human Genetics . 73 . 5 . 1199–207 . Nov 2003 . 14566705 . 1180499 . 10.1086/379524 .

Notes and References

1. Asuru AI, Mellor H, Thomas NS, Yu L, Chen JJ, Crosby JS, Hartson SD, Kimball SR, Jefferson LS, Matts RL . Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human . Biochimica et Biophysica Acta . 1307 . 3 . 309–17 . Jul 1996 . 8688466 . 10.1016/0167-4781(96)00054-1 .
2. Web site: Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa.
3. Anthony TG, Fabian JR, Kimball SR, Jefferson LS . Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation . Biochimica et Biophysica Acta . 1492 . 1 . 56–62 . Jun 2000 . 10858531 . 10.1016/S0167-4781(00)00062-2 .
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .