EIF2B3 explained

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.^{[1] [2]}

Further reading

• Welsh GI, Miyamoto S, Price NT . T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. . J. Biol. Chem. . 271 . 19 . 11410–3 . 1996 . 8626696 . 10.1074/jbc.271.19.11410 . etal. free .
• Gomez E, Pavitt GD . Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. . Mol. Cell. Biol. . 20 . 11 . 3965–76 . 2000 . 10805739 . 10.1128/MCB.20.11.3965-3976.2000 . 85753 .
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS . Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. . Biochim. Biophys. Acta . 1492 . 1 . 56–62 . 2000 . 10858531 . 10.1016/S0167-4781(00)00062-2.
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Williams DD, Price NT, Loughlin AJ, Proud CG . Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. . J. Biol. Chem. . 276 . 27 . 24697–703 . 2001 . 11323413 . 10.1074/jbc.M011788200 . free .
• van der Knaap MS, Leegwater PA, Könst AA . Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter. . Ann. Neurol. . 51 . 2 . 264–70 . 2002 . 11835386 . 10.1002/ana.10112 . 1849575 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Fogli A, Dionisi-Vici C, Deodato F . A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation. . Neurology . 59 . 12 . 1966–8 . 2003 . 12499492 . 10.1212/01.wnl.0000041666.76863.47. 13129517 . etal.
• Fogli A, Rodriguez D, Eymard-Pierre E . Ovarian failure related to eukaryotic initiation factor 2B mutations. . Am. J. Hum. Genet. . 72 . 6 . 1544–50 . 2003 . 12707859 . 10.1086/375404 . 1180314 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Fogli A, Schiffmann R, Hugendubler L . Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients. . Eur. J. Hum. Genet. . 12 . 7 . 561–6 . 2005 . 15054402 . 10.1038/sj.ejhg.5201189 . etal. free .
• Li W, Wang X, Van Der Knaap MS, Proud CG . Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. . Mol. Cell. Biol. . 24 . 8 . 3295–306 . 2004 . 15060152 . 10.1128/MCB.24.8.3295-3306.2004 . 381664 .
• Van Haren K, van der Voorn JP, Peterson DR . The life and death of oligodendrocytes in vanishing white matter disease. . J. Neuropathol. Exp. Neurol. . 63 . 6 . 618–30 . 2004 . 15217090 . 10.1093/jnen/63.6.618. etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV . Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases. . Biochem. Biophys. Res. Commun. . 338 . 4 . 1766–72 . 2006 . 16288713 . 10.1016/j.bbrc.2005.10.150 .
• Mikami S, Masutani M, Sonenberg N . An efficient mammalian cell-free translation system supplemented with translation factors. . Protein Expr. Purif. . 46 . 2 . 348–57 . 2006 . 16289705 . 10.1016/j.pep.2005.09.021 . etal.

Notes and References

1. Kruger M, Beger C, Li QX, Welch PJ, Tritz R, Leavitt M, Barber JR, Wong-Staal F . Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach . Proc Natl Acad Sci U S A . 97 . 15 . 8566–71 . Aug 2000 . 10900014 . 26988 . 10.1073/pnas.97.15.8566 . 2000PNAS...97.8566K . free .
2. Web site: Entrez Gene: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa.