EIF2B1 explained

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.^[1]

Interactions

EIF2B1 has been shown to interact with EIF2B5.^{[2] [3]}

Further reading

• Hershey JW . Translational control in mammalian cells . Annu. Rev. Biochem. . 60 . 717–55 . 1991 . 1883206 . 10.1146/annurev.bi.60.070191.003441 .
• Flowers KM, Mellor H, Kimball SR, Jefferson LS . Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B . Biochim. Biophys. Acta . 1264 . 2 . 163–7 . 1996 . 7495858 . 10.1016/0167-4781(95)00160-i .
• Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG . T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3 . J. Biol. Chem. . 271 . 19 . 11410–3 . 1996 . 8626696 . 10.1074/jbc.271.19.11410 . free .
• Yang W, Hinnebusch AG . Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2 . Mol. Cell. Biol. . 16 . 11 . 6603–16 . 1996 . 8887689 . 231662 . 10.1128/MCB.16.11.6603.
• Klein U, Ramirez MT, Kobilka BK, von Zastrow M . A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B . J. Biol. Chem. . 272 . 31 . 19099–102 . 1997 . 9235896 . 10.1074/jbc.272.31.19099 . free .
• Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS . Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B . J. Biol. Chem. . 273 . 5 . 3039–44 . 1998 . 9446619 . 10.1074/jbc.273.5.3039 . free .
• Gomez E, Pavitt GD . Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation . Mol. Cell. Biol. . 20 . 11 . 3965–76 . 2000 . 10805739 . 85753 . 10.1128/MCB.20.11.3965-3976.2000 .
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS . Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation . Biochim. Biophys. Acta . 1492 . 1 . 56–62 . 2000 . 10858531 . 10.1016/S0167-4781(00)00062-2 .
• Williams DD, Price NT, Loughlin AJ, Proud CG . Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein . J. Biol. Chem. . 276 . 27 . 24697–703 . 2001 . 11323413 . 10.1074/jbc.M011788200 . free .
• van der Knaap MS, Leegwater PA, Könst AA, Visser A, Naidu S, Oudejans CB, Schutgens RB, Pronk JC . Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter . Ann. Neurol. . 51 . 2 . 264–70 . 2002 . 11835386 . 10.1002/ana.10112 . 1849575 .
• Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E . A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation . Neurology . 59 . 12 . 1966–8 . 2003 . 12499492 . 10.1212/01.wnl.0000041666.76863.47 . 13129517 .
• Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O . Ovarian Failure Related to Eukaryotic Initiation Factor 2B Mutations . Am. J. Hum. Genet. . 72 . 6 . 1544–50 . 2003 . 12707859 . 1180314 . 10.1086/375404 .
• van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC . eIF2B-Related Disorders: Antenatal Onset and Involvement of Multiple Organs . Am. J. Hum. Genet. . 73 . 5 . 1199–207 . 2004 . 14566705 . 1180499 . 10.1086/379524 .
• Richardson JP, Mohammad SS, Pavitt GD . Mutations Causing Childhood Ataxia with Central Nervous System Hypomyelination Reduce Eukaryotic Initiation Factor 2B Complex Formation and Activity . Mol. Cell. Biol. . 24 . 6 . 2352–63 . 2004 . 14993275 . 355856 . 10.1128/MCB.24.6.2352-2363.2004 .
• Li W, Wang X, Van Der Knaap MS, Proud CG . Mutations Linked to Leukoencephalopathy with Vanishing White Matter Impair the Function of the Eukaryotic Initiation Factor 2B Complex in Diverse Ways . Mol. Cell. Biol. . 24 . 8 . 3295–306 . 2004 . 15060152 . 381664 . 10.1128/MCB.24.8.3295-3306.2004 .
• Van Haren K, van der Voorn JP, Peterson DR, van der Knaap MS, Powers JM . The life and death of oligodendrocytes in vanishing white matter disease . J. Neuropathol. Exp. Neurol. . 63 . 6 . 618–30 . 2004 . 15217090 . 10.1093/jnen/63.6.618. free .
• Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM . Identification of novel CBP interacting proteins in embryonic orofacial tissue . Biochem. Biophys. Res. Commun. . 329 . 3 . 1010–7 . 2005 . 15752756 . 10.1016/j.bbrc.2005.02.075 .

Notes and References

1. Web site: Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa.
2. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
3. Anthony TG, Fabian JR, Kimball SR, Jefferson LS . Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation . Biochim. Biophys. Acta . 1492 . 1 . 56–62 . June 2000 . 10858531 . 10.1016/S0167-4781(00)00062-2 .