EIF1AY explained

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.^{[1] [2]}

Like its X-chromosomal counterpart EIF1AX, it encodes an isoform of eukaryotic translation initiation factor 1A (EIF1A). EIF1A is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. It has one amino acid difference (M50L) from EIF1AX.

Further reading

• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . vanc. Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Fortna A . Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution . PLOS Biol. . 2 . 7 . E207 . 2006 . 15252450 . 10.1371/journal.pbio.0020207 . 449870 . vanc. Kim Y . MacLaren E . 3 . Marshall . Kriste . Hahn . Gretchen . Meltesen . Lynne . Brenton . Matthew . Hink . Raquel . Burgers . Sonya . free .
• Agate RJ, Choe M, Arnold AP . Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches . Mol. Biol. Evol. . 21 . 2 . 384–96 . 2004 . 14660691 . 10.1093/molbev/msh027 . free .
• Skaletsky H . The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes . Nature . 423 . 6942 . 825–37 . 2003 . 12815422 . 10.1038/nature01722 . vanc. Kuroda-Kawaguchi T . Minx PJ . 3 . Cordum . Holland S. . Hillier . Ladeana . Brown . Laura G. . Repping . Sjoerd . Pyntikova . Tatyana . Ali . Johar . 2003Natur.423..825S . free .
• Marintchev A, Kolupaeva VG, Pestova TV, Wagner G . Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners . Proc. Natl. Acad. Sci. U.S.A. . 100 . 4 . 1535–40 . 2003 . 12569173 . 10.1073/pnas.0437845100 . 149867 . 2003PNAS..100.1535M . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .

Notes and References

1. Lahn BT, Page DC . Functional coherence of the human Y chromosome . Science . 278 . 5338 . 675–80 . Nov 1997 . 9381176 . 10.1126/science.278.5338.675 . 1997Sci...278..675L .
2. Web site: Entrez Gene: EIF1AY eukaryotic translation initiation factor 1A, Y-linked.