| EP300 interacting inhibitor of differentiation 2 | |
| Hgncid: | 28292 |
| Symbol: | EID2 |
| Altsymbols: | CRI2 |
| Entrezgene: | 163126 |
| Omim: | 609773 |
| Refseq: | NM_153232 |
| Uniprot: | Q8N6I1 |
| Chromosome: | 19 |
| Arm: | q |
| Band: | 13.2 |
EP300 interacting inhibitor of differentiation 2, also known as EID2 is a human gene.[1]
The protein encoded by this gene may function as an endogenous suppressor of TGF-beta signaling and inhibits differentiation by blocking the histone acetyltransferase activity of p300, class I histone deacetylase, HDACs. The N-terminal portion of EID-2 was required for the binding to HDACs. This region was also involved in the transcriptional repression and nuclear localization, suggesting the importance of the involvement of HDACs in the EID-2 function. EID-2 inhibits TGF-beta/Smad transcriptional responses. EID-2 interacts constitutively with Smad proteins, and most strongly with Smad3. Stable expression of EID-2 in the TGF-beta1-responsive cell line inhibits endogenous Smad3-Smad4 complex formation and TGF-beta1-induced expression of p21 and p15.EID-2 displays developmentally regulated expression with high levels in adult heart and brain. Overexpression of EID-2 inhibits muscle-specific gene expression through inhibition of MyoD-dependent transcription. This inhibitory effect on gene expression can be explained by EID-2's ability to associate with and inhibit the acetyltransferase activity of p300.