EHF (gene) explained

ETS homologous factor is a protein that in humans is encoded by the EHF gene.^{[1] [2]} This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.

Further reading

Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.

Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).

References

• Fujikawa M, Katagiri T, Tugores A . ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. . Cancer Sci. . 98 . 9 . 1468–75 . 2007 . 17627613 . 10.1111/j.1349-7006.2007.00543.x . 2539168 . etal. free . 11159184 .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.
• Park C, Lee I, Kang WK . Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis. . Mol. Cancer Ther. . 5 . 12 . 3191–6 . 2007 . 17172423 . 10.1158/1535-7163.MCT-06-0570 . free .
• Lim JH, Cho JY, Park YB . ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites. . Biochem. Biophys. Res. Commun. . 350 . 3 . 736–41 . 2006 . 17027647 . 10.1016/j.bbrc.2006.09.102 . etal.
• Taylor TD, Noguchi H, Totoki Y . Human chromosome 11 DNA sequence and analysis including novel gene identification. . Nature . 440 . 7083 . 497–500 . 2006 . 16554811 . 10.1038/nature04632 . 2006Natur.440..497T . etal. free .
• Appel S, Bringmann A, Grünebach F . Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. . Blood . 107 . 8 . 3265–70 . 2006 . 16380452 . 10.1182/blood-2005-06-2480 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Silverman ES, Baron RM, Palmer LJ . Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. . Am. J. Respir. Cell Mol. Biol. . 27 . 6 . 697–704 . 2003 . 12444029 . 10.1165/rcmb.2002-0011oc. etal.
• Tugores A, Le J, Sorokina I . The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades. . J. Biol. Chem. . 276 . 23 . 20397–406 . 2001 . 11259407 . 10.1074/jbc.M010930200 . etal. free .
• Dias Neto E, Correa RG, Verjovski-Almeida S . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . etal. free .
• Kas K, Finger E, Grall F . ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. . J. Biol. Chem. . 275 . 4 . 2986–98 . 2000 . 10644770 . 10.1074/jbc.275.4.2986 . etal. free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH . Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF . Biochem Biophys Res Commun . 264 . 1 . 119–26 . Nov 1999 . 10527851 . 10.1006/bbrc.1999.1493 .
2. Web site: Entrez Gene: EHF ets homologous factor.